Document Detail


Efficacy and specificity of immunotherapy with laboratory animal allergen extracts.
MedLine Citation:
PMID:  7372963     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The clinical and immunologic response to immunotherapy with laboratory animal allergens was evaluated. There were 23 patients; 11 had received immunotherapy with 12 different extracts (five mouse, six rat, one rabbit), and 12 were matched untreated patients. As a group, nine of 23 had seasonal hay fever. Among the treated patients nine of 11 subjectively improved with immunotherapy. Blocking antibody titers were determined by serum inhibition of allergen-induced histamine release. Treated patients had mean blocking antibody levels of G30 = 59.3 +/- 38.7. In the untreated patients the antibody level was low (G30 = 4.6 +/- 3.6). The difference between the two groups was highly significant (t test p less than 0.001). The blocking antibody level correlates with both the final weekly allergen dose and also the cumulative allergen dose received during immunotherapy. When pretreatment sera were available a temporal rise in blocking antibody was demonstrated during immunotherapy. In patients allergic to several laboratory animals and treated with one allergen, the blocking antibody response was predominantly specific to the allergen used in immunotherapy. This indicates a lack of cross-reactivity in the IgG response to the major animal allergens. When immunotherapy was discontinued in four patients there was a dramatic decrease in the blocking titer, and after 24 mo the levels were the same as those of untreated patients.
Authors:
U Wahn; R P Siraganian
Related Documents :
11348533 - Clinical description of encephalopathic syndromes and risk factors for their occurrence...
15971473 - Adverse drug reactions to a cephalosporins in hospitalized patients with a history of p...
3142723 - Differentiation of sarcoidosis from tuberculosis using an enzyme-linked immunosorbent a...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  65     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  1980 Jun 
Date Detail:
Created Date:  1980-07-26     Completed Date:  1980-07-26     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  413-21     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Allergens / administration & dosage*
Animals
Antibodies*
Antibody Specificity*
Asthma / therapy
Binding, Competitive
Cricetinae
Cross Reactions
Female
Guinea Pigs
Humans
Hypersensitivity / therapy
Immunotherapy*
Male
Mice
Middle Aged
Rabbits
Rats
Rhinitis, Allergic, Seasonal / therapy
Chemical
Reg. No./Substance:
0/Allergens; 0/Antibodies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Skin reactivity to purified pollen allergens in highly ragweed-sensitive individuals.
Next Document:  Comparison of cord blood immunoglobulin E concentrations and maternal allergy for the prediction of ...