Document Detail

Efficacy of somatostatin and its analogues in pancreatic surgery and pancreatic disorders.
MedLine Citation:
PMID:  8813484     Owner:  NLM     Status:  MEDLINE    
Major pancreatic resection is still accompanied by considerable morbidity (35%) and mortality (10%). Typical complications, such as pancreatic fistula and abscess, are chiefly associated with exocrine pancreatic secretion. The hormone somatostatin and its analogue octreotide are well known as potent inhibitors of exocrine pancreatic secretion. In two randomised, double-blind, placebo-controlled, multicentre trials we assessed the prophylactic effect of the perioperative inhibition of exocrine pancreatic secretion by octreotide to prevent postoperative complications. Each patient received 3 X 100 micrograms/day octreotide or placebo subcutaneously. A significant reduction in fistula, abscess, fluid collection, sepsis and postoperative pancreatitis occurred with patients undergoing pancreatic resection for cancer. Results were similar in a second study, using the same protocol but recruiting only patients with chronic pancreatitis. A new randomised, controlled multicentre trial is also described, in which 300 patients with severe acute pancreatitis are being treated with or without octreotide in double-blind fashion. The results will clarify the influence of inhibition of exocrine pancreatic secretion by octreotide on the course of acute pancreatitis, and hence its potential, through inhibition of digestive enzyme secretion, as a treatment for acute pancreatitis.
H Friess; M W Büchler
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Digestion     Volume:  57 Suppl 1     ISSN:  0012-2823     ISO Abbreviation:  Digestion     Publication Date:  1996  
Date Detail:
Created Date:  1997-01-14     Completed Date:  1997-01-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0150472     Medline TA:  Digestion     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  97-102     Citation Subset:  IM    
Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Switzerland.
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MeSH Terms
Aged, 80 and over
Antineoplastic Agents, Hormonal / therapeutic use*
Chronic Disease
Double-Blind Method
Gastrointestinal Agents / therapeutic use*
Hormone Antagonists / therapeutic use*
Middle Aged
Octreotide / therapeutic use*
Pancreas / surgery*
Pancreatic Diseases / drug therapy,  surgery,  therapy*
Pancreatic Neoplasms / complications,  drug therapy,  ultrasonography
Pancreatitis / drug therapy,  surgery,  therapy
Postoperative Complications / prevention & control
Prospective Studies
Somatostatin / analogs & derivatives*,  therapeutic use*
Reg. No./Substance:
0/Antineoplastic Agents, Hormonal; 0/Gastrointestinal Agents; 0/Hormone Antagonists; 51110-01-1/Somatostatin; 83150-76-9/Octreotide

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