| Efficacy of a sodium hyaluronate-carboxycellulose membrane (seprafilm) for reducing the risk of early postoperative small bowel obstruction in patients with gynecologic malignancies. | |
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MedLine Citation:
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PMID: 20130522 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the effect of a sodium hyaluronate and carboxymethylcellulose membrane (Seprafilm) on early postoperative small bowel obstruction (EPSBO) in patients with gynecologic malignancies. METHODS: One hundred forty-five patients who had Seprafilm placed during gynecological surgery between April 2002 and March 2007 (Seprafilm group) were compared with a historical control group of patients managed without Seprafilm between January 1997 and March 2002. All patients undergoing primary surgery with pelvic or combined pelvic and para-aortic lymphadenectomy for gynecological malignancies were retrospectively assessed for EPSBO and surgical infections. RESULTS: The incidence of EPSBO was significantly lower (P < 0.05) in the Seprafilm group (3.1%, 6/191) than in the control group (13.9%, 25/180). According to logistic regression analysis, the use of Seprafilm (odds ratio, 0.18; 95% confidence interval, 0.07-0.47; P < 0.0005) and the performance of pelvic lymphadenectomy alone (odds ratio, 0.27; 95% confidence interval, 0.09-0.78; P < 0.02) were independent predictors of a lower rate of EPSBO. The incidence of surgical infection showed no significant difference between the Seprafilm group (3.6%) and the control group (6.7%). CONCLUSIONS: Placement of Seprafilm helped to prevent EPSBO and had no significant adverse effect on surgical infections in patients who underwent lymphadenectomy for gynecological malignancy. |
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Authors:
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Tsutomu Tabata; Tomohisa Kihira; Takaya Shiozaki; Kouji Tanida; Eiji Kondo; Kenji Nagao; Toshiharu Okugawa; Norimasa Sagawa |
Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society Volume: 20 ISSN: 1525-1438 ISO Abbreviation: Int. J. Gynecol. Cancer Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-04 Completed Date: 2010-04-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9111626 Medline TA: Int J Gynecol Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 188-93 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Mie University School of Medicine, 2-174 Edobashi, Tsu City, Mie 514-8507, Japan. tabatat@clin.medic.mie-u.ac.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Carcinoma / epidemiology, surgery* Cellulose, Oxidized / administration & dosage* Female Genital Neoplasms, Female / epidemiology, surgery* Hemostasis, Surgical / methods Hemostatics / administration & dosage Humans Hyaluronic Acid / administration & dosage*, therapeutic use Incidence Intestinal Obstruction / epidemiology, prevention & control* Intestine, Small / drug effects, pathology Membranes, Artificial Middle Aged Models, Biological Postoperative Complications / epidemiology, prevention & control* Retrospective Studies Risk Factors Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Hemostatics; 0/Membranes, Artificial; 0/Seprafilm; 9004-61-9/Hyaluronic Acid; 9032-53-5/Cellulose, Oxidized |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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