Document Detail

Efficacy of a sodium hyaluronate-carboxycellulose membrane (seprafilm) for reducing the risk of early postoperative small bowel obstruction in patients with gynecologic malignancies.
MedLine Citation:
PMID:  20130522     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the effect of a sodium hyaluronate and carboxymethylcellulose membrane (Seprafilm) on early postoperative small bowel obstruction (EPSBO) in patients with gynecologic malignancies. METHODS: One hundred forty-five patients who had Seprafilm placed during gynecological surgery between April 2002 and March 2007 (Seprafilm group) were compared with a historical control group of patients managed without Seprafilm between January 1997 and March 2002. All patients undergoing primary surgery with pelvic or combined pelvic and para-aortic lymphadenectomy for gynecological malignancies were retrospectively assessed for EPSBO and surgical infections. RESULTS: The incidence of EPSBO was significantly lower (P < 0.05) in the Seprafilm group (3.1%, 6/191) than in the control group (13.9%, 25/180). According to logistic regression analysis, the use of Seprafilm (odds ratio, 0.18; 95% confidence interval, 0.07-0.47; P < 0.0005) and the performance of pelvic lymphadenectomy alone (odds ratio, 0.27; 95% confidence interval, 0.09-0.78; P < 0.02) were independent predictors of a lower rate of EPSBO. The incidence of surgical infection showed no significant difference between the Seprafilm group (3.6%) and the control group (6.7%). CONCLUSIONS: Placement of Seprafilm helped to prevent EPSBO and had no significant adverse effect on surgical infections in patients who underwent lymphadenectomy for gynecological malignancy.
Tsutomu Tabata; Tomohisa Kihira; Takaya Shiozaki; Kouji Tanida; Eiji Kondo; Kenji Nagao; Toshiharu Okugawa; Norimasa Sagawa
Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  International journal of gynecological cancer : official journal of the International Gynecological Cancer Society     Volume:  20     ISSN:  1525-1438     ISO Abbreviation:  Int. J. Gynecol. Cancer     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-04     Completed Date:  2010-04-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111626     Medline TA:  Int J Gynecol Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  188-93     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Mie University School of Medicine, 2-174 Edobashi, Tsu City, Mie 514-8507, Japan.
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MeSH Terms
Carcinoma / epidemiology,  surgery*
Cellulose, Oxidized / administration & dosage*
Genital Neoplasms, Female / epidemiology,  surgery*
Hemostasis, Surgical / methods
Hemostatics / administration & dosage
Hyaluronic Acid / administration & dosage*,  therapeutic use
Intestinal Obstruction / epidemiology,  prevention & control*
Intestine, Small / drug effects,  pathology
Membranes, Artificial
Middle Aged
Models, Biological
Postoperative Complications / epidemiology,  prevention & control*
Retrospective Studies
Risk Factors
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Hemostatics; 0/Membranes, Artificial; 0/Seprafilm; 9004-61-9/Hyaluronic Acid; 9032-53-5/Cellulose, Oxidized

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