Document Detail


Efficacy of six-dose regimen of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria, three years after its introduction into Ethiopia.
MedLine Citation:
PMID:  19585891     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We assessed the clinical and parasitological efficacy of six-dose regimen of artemether-lumefantrine (AL) (Coartem) for treating uncomplicated P. falciparum malaria three years after its introduction into Ethiopia. A total of 102 patients (mean age: 15.7 years; age range: 1-50 years) were enrolled in the study and followed-up for 28 days based on WHO protocol. Treatment with AL resulted in 100% adequate clinical and parasitological response (ACPR). No severe side-effect of the drug was observed. All patients had rapid clinical and parasitological responses. None of the subject was found to be positive for asexual or sexual stage of the parasite after day 3. A significant increase in the mean of haemoglobin level was observed on day 28 posttreatment (11.4 g/dL on day 0 vs 12.3 g/dL on day 28, p < 0.05). Thus, artemisinin-based combination therapies (ACTs) seem to mitigate not only the problem of drug resistance malaria but also the transmission of the disease. Nevertheless, monitoring ACT therapeutic efficacy is crucial in Ethiopia.
Authors:
T Kefyalew; A Animut; T Tamene; D Jima; A Hailemariam; M Legesse
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Parasite (Paris, France)     Volume:  16     ISSN:  1252-607X     ISO Abbreviation:  Parasite     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-07-09     Completed Date:  2009-10-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9437094     Medline TA:  Parasite     Country:  France    
Other Details:
Languages:  eng     Pagination:  129-34     Citation Subset:  IM    
Affiliation:
Aklilu Lemma Institute of Pathobiology, Addis Ababa University, P.O.B. 1176, Ethiopia.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antimalarials / administration & dosage,  therapeutic use*
Artemisinins / administration & dosage,  therapeutic use*
Child
Child, Preschool
Drug Combinations
Ethanolamines / administration & dosage,  therapeutic use*
Ethiopia
Female
Fluorenes / administration & dosage,  therapeutic use*
Humans
Infant
Malaria, Falciparum / complications,  drug therapy*
Malaria, Vivax / complications,  drug therapy
Male
Middle Aged
Treatment Outcome
Young Adult
Chemical
Reg. No./Substance:
0/Antimalarials; 0/Artemisinins; 0/Drug Combinations; 0/Ethanolamines; 0/Fluorenes; 0/artemether-lumefantrine combination

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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