| Efficacy of silodosin for relieving benign prostatic obstruction: prospective pressure flow study. | |
| | |
MedLine Citation:
|
PMID: 23234615 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: We investigated the effect of the new sympathetic α1A-adrenoceptor antagonist silodosin for relieving benign prostatic obstruction by pressure flow study. MATERIALS AND METHODS: In this open, nonblinded, prospective study we administered 8 mg silodosin daily for 4 weeks in 60 patients with lower urinary tract symptoms associated with benign prostatic enlargement. As a primary outcome measure, we assessed changes in bladder function and benign prostatic obstruction using pressure flow study. As secondary outcome measures, changes in subjective symptoms and quality of life were assessed by the International Prostate Symptom Score. Objective changes in urination status were also assessed by free uroflowmetry in terms of maximum flow rate and post-void residual urine volume. RESULTS: A total of 57 patients were enrolled for analysis. In the storage phase of the pressure flow study bladder capacity at first desire to void increased significantly with no significant change in maximum cystometric capacity. Of 24 patients 14 (58.3%) with uninhibited detrusor contractions before administration showed apparent improvement in detrusor overactivity after administration, including 6 in whom uninhibited contractions disappeared. In the voiding phase mean detrusor pressure at maximum flow significantly decreased from 72.5 to 51.4 cm H(2)O. The mean bladder outlet obstruction index decreased significantly from 60.6 to 33.8. Obstruction grade assessed by the Schaefer nomogram improved in all except 1 patient. Total symptom and quality of life scores, maximum flow rate and post-void residual urine volume on free uroflowmetry significantly improved. CONCLUSIONS: Silodosin improved lower urinary tract symptoms by improving bladder storage function and relieving benign prostatic obstruction. |
| | |
Authors:
|
Yoshihisa Matsukawa; Momokazu Gotoh; Tomonori Komatsu; Yasuhito Funahashi; Naoto Sassa; Ryohei Hattori |
Related Documents
:
|
11329225 - Evaluation of diastolic function. 11288805 - Gender and the relationship between resting heart rate and left ventricular geometry. 6097405 - Functional characteristics and responses to adrenergic stimulation of isolated heart pr... 16455425 - Preservation of ventricular function in amateur athletes after completion of a marathon. 2963705 - Systolic and diastolic dysfunction during atrial pacing in conscious dogs with left ven... 16478835 - Translating research to clinical practice: a 1-year experience with implementing early ... |
Publication Detail:
|
Type: Clinical Trial; Journal Article |
Journal Detail:
|
Title: The Journal of urology Volume: 189 ISSN: 1527-3792 ISO Abbreviation: J. Urol. Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2012-12-13 Completed Date: 2013-02-11 Revised Date: 2013-05-22 |
Medline Journal Info:
|
Nlm Unique ID: 0376374 Medline TA: J Urol Country: United States |
Other Details:
|
Languages: eng Pagination: S117-21 Citation Subset: AIM; IM |
Copyright Information:
|
Copyright © 2013 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Japan. yoshi44@med.nagoya-u.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenergic alpha-1 Receptor Antagonists
/
therapeutic use* Aged Aged, 80 and over Humans Indoles / therapeutic use* Male Middle Aged Prospective Studies Prostatic Hyperplasia / complications Urinary Bladder Neck Obstruction / drug therapy*, etiology, physiopathology Urodynamics |
| Chemical | |
Reg. No./Substance:
|
0/Adrenergic alpha-1 Receptor Antagonists; 0/Indoles; CUZ39LUY82/silodosin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Association of lower urinary tract symptoms and the metabolic syndrome: results from the Boston area...
Next Document: Increasing hospital admission rates for urological complications after transrectal ultrasound guided...