Document Detail


Efficacy of sildenafil citrate at 12 hours after dosing: re-exploring the therapeutic window.
MedLine Citation:
PMID:  15306108     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: This open-label study investigated the efficacy of sildenafil citrate at 12 hours postdose among prior treatment responders. PATIENTS AND METHODS: Eight 100-mg doses of sildenafil were provided to 40 eligible patients with erectile dysfunction (ED), who were to record the results of each sexual attempt in a patient diary. Each patient was instructed to make a sexual attempt at 1 and 12 hours postdose on 4 occasions (part 1) and only at 12 hours postdose on 4 subsequent occasions (part 2). RESULTS: Of 40 enrolled patients, 34 (85%) completed the study. In these evaluable patients, 97% and 74% of patients achieved erections that resulted in successful intercourse at 1 hour and 12 hours postdose, respectively. There was a nonsignificant reduction in the percentage of responders at 12 hours during part 1 versus part 2 of this study (71% versus 78%). CONCLUSIONS: This study demonstrates that, in the majority of these patients with ED, sildenafil remains clinically active 12 hours after administration. Larger studies may be necessary to confirm and clarify the therapeutic window of sildenafil.
Authors:
Ignacio Moncada; José Jara; David Subirá; Irene Castaño; Carlos Hernández
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European urology     Volume:  46     ISSN:  0302-2838     ISO Abbreviation:  Eur. Urol.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-12     Completed Date:  2005-02-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7512719     Medline TA:  Eur Urol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  357-60; discussion 360-1     Citation Subset:  IM    
Affiliation:
Urology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain. imoncada@md.infonegocio.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Dose-Response Relationship, Drug
Drug Administration Schedule
Erectile Dysfunction / drug therapy*
Humans
Male
Medical Records
Middle Aged
Piperazines / administration & dosage*
Prospective Studies
Purines
Sulfones
Time Factors
Treatment Outcome
Vasodilator Agents / administration & dosage*
Chemical
Reg. No./Substance:
0/Piperazines; 0/Purines; 0/Sulfones; 0/Vasodilator Agents; 139755-83-2/sildenafil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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