| Efficacy of a short course (10 days) of high-dose meglumine antimonate with or without interferon-gamma in treating cutaneous leishmaniasis in Guatemala. | |
| | |
MedLine Citation:
|
PMID: 8011819 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Sixty-six Guatemalan men with parasitologically confirmed cutaneous leishmaniasis, due most commonly to Leishmania braziliensis, were randomly assigned to receive one of three treatment regimens: meglumine antimonate (meglumine) for 20 days; meglumine for 10 days; and meglumine for 10 days plus alternate-day injections of interferon-gamma. In each group, meglumine was given intravenously as 20 mg of antimony/(kg of body weight.d). All treatment regimens were associated with similar response rates: the lesions of 19 (90%) of 21 patients who received meglumine for 20 days, 18 (90%) of 20 patients who received meglumine for 10 days, and all 22 patients who received meglumine plus interferon-gamma were completely reepithelialized by 13 weeks. In addition, for patients receiving all treatment regimens, test-of-cure cultures for Leishmania were negative and reactivation of lesions did not occur during 12 months of follow-up. The high efficacy of our 10-day course of meglumine indicates that the currently recommended duration of 20 days may be unnecessary for infections caused by L. braziliensis and suggests that a 10-day course of high-dose antimony should be tested as therapy for cutaneous leishmaniasis in other geographic areas. |
| | |
Authors:
|
B A Arana; T R Navin; F E Arana; J D Berman; F Rosenkaimer |
Related Documents
:
|
16890599 - Peginterferon-alfa2a plus ribavirin for 48 versus 72 weeks in patients with detectable ... 6505269 - High dose rdna human alpha 2 interferon therapy in patients with advanced colorectal ad... 16232219 - Chemokines in onchocerciasis patients after a single dose of ivermectin. 8314479 - Treatment of chronic hepatitis c with recombinant interferon alfa-2b. 17956829 - Effect of adherence to haart on virologic outcome and on the selection of resistance-co... 1932299 - Interferon alpha-2b in the long-term treatment of essential thrombocythemia. 12800379 - Auditory brainstem response in children with iron deficiency anemia. 2814379 - Sagittal split osteotomy of the mandible without postoperative intermaxillary fixation.... 18371559 - Syncope predicts the outcome of cardiomyopathy patients: analysis of the scd-heft study. |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Volume: 18 ISSN: 1058-4838 ISO Abbreviation: Clin. Infect. Dis. Publication Date: 1994 Mar |
Date Detail:
|
Created Date: 1994-07-27 Completed Date: 1994-07-27 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9203213 Medline TA: Clin Infect Dis Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 381-4 Citation Subset: IM |
Affiliation:
|
Division of Parasitic Diseases, Centers for Diseases Control and Prevention, Atlanta, Georgia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Drug Administration Schedule Guatemala Humans Interferon-gamma, Recombinant / administration & dosage* Leishmaniasis, Cutaneous / drug therapy* Male Meglumine / administration & dosage* |
| Chemical | |
Reg. No./Substance:
|
0/Interferon-gamma, Recombinant; 6284-40-8/Meglumine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clinical epidemiological study of 171 cases of cryptococcosis.
Next Document: Pulmonary infection due to Legionella cincinnatiensis in renal transplant recipients: two cases and ...