| Efficacy of selective α1A adrenoceptor antagonist silodosin in the medical expulsive therapy for ureteral stones. | |
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MedLine Citation:
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PMID: 21707766 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recently, we reported that α1A adrenoceptor (AR) is the main participant in phenylephrine-induced human ureteral contraction. We therefore decided to carry out a prospective randomized study to evaluate the effects of silodosin, a selective α1A AR antagonist, as a medical expulsive therapy for ureteral stones. A total of 187 male patients, who were referred to our department for the management of symptomatic unilateral ureteral calculi of less than 10 mm, were randomly divided into two groups: group A (92 patients), who were instructed to drink 2 L of water daily, and group B (95 patients), who received the same instruction and were also given silodosin (8 mg/daily) for a maximum of 8 weeks. Expulsion rate, mean expulsion time and need for analgesics were examined. Overall, the mean expulsion time was 15.19 ± 7.14 days for group A and 10.27 ± 8.35 days for group B (P = 0.0058). In cases involving distal ureteral stones, the mean expulsion time was 13.40 ± 5.90 and 9.29 ± 5.91 days, respectively (P = 0.012). For stones of 1-5 mm in diameter, the mean expulsion time was 14.28 ± 6.35 and 9.56 ± 8.45 days, respectively (P = 0.017). For stones of 6-9 mm in diameter, the stone expulsion rate was 30.4% and 52.2% (P = 0.036), and the mean expulsion time was 21.00 ± 9.9 and 11.33 ± 8.31 days, respectively (P = 0.038). Herein, we report the first on silodosin in the management of ureteral lithiasis. Our findings suggest that silodosin might have potential as a medical expulsive therapy for ureteral stones. |
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Authors:
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Yasunori Itoh; Atsushi Okada; Takahiro Yasui; Shuzo Hamamoto; Masahito Hirose; Yoshiyuki Kojima; Keiichi Tozawa; Shoichi Sasaki; Kenjiro Kohri |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2011-06-26 |
Journal Detail:
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Title: International journal of urology : official journal of the Japanese Urological Association Volume: 18 ISSN: 1442-2042 ISO Abbreviation: Int. J. Urol. Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-09-02 Completed Date: 2012-01-11 Revised Date: 2013-05-22 |
Medline Journal Info:
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Nlm Unique ID: 9440237 Medline TA: Int J Urol Country: Australia |
Other Details:
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Languages: eng Pagination: 672-4 Citation Subset: IM |
Copyright Information:
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© 2011 The Japanese Urological Association. |
Affiliation:
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Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan. yasunori2009@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-1 Receptor Antagonists
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therapeutic use* Adult Aged Analgesics / therapeutic use Drinking Humans Indoles / therapeutic use* Male Middle Aged Prospective Studies Treatment Outcome Ureteral Calculi / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-1 Receptor Antagonists; 0/Analgesics; 0/Indoles; CUZ39LUY82/silodosin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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