Document Detail

Efficacy and safety of twice daily administration of cefpirome in the empiric treatment of sepsis.
MedLine Citation:
PMID:  10511765     Owner:  NLM     Status:  MEDLINE    
Cefpirome is a fourth-generation cephalosporin with good activity against both gram-positive and gram-negative bacteria. A multicentre trial was performed to study the efficacy and safety of cefpirome 2 g twice daily in the treatment of sepsis. Sixty-three cases were recruited from 10 hospitals from April 1996 to January 1998. Fifty seven cases could be evaluated according to the protocol. The APACHE II score was used to measure severity of illness, with 46.9 per cent of patients having APACHE II score more than 10 and two patients more than 20; both were cured. The most common pathogens were gram-negative bacteria with E. coli predominating 16/40 (40.0%), followed by Klebsiella 8/40 (20.0%). The overall clinical success rates were 54 out of 57 patients (94.7%). In patients with positive blood culture, the clinical cures were achieved for 20/22 (90.9%). Cefpirome showed good efficacy and safety in the empirical treatment of suspected bacteremia or sepsis.
P Suwangool; C Suttinont; C Bowonwatanuwong; A Rajanuwong; S A Kulpradist; V Dusitnanond; P Chayakul; P Chetchotisakd; S Leelasupasri; N Aswapokee
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the Medical Association of Thailand = Chotmaihet thangphaet     Volume:  82     ISSN:  0125-2208     ISO Abbreviation:  J Med Assoc Thai     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-10-22     Completed Date:  1999-10-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7507216     Medline TA:  J Med Assoc Thai     Country:  THAILAND    
Other Details:
Languages:  eng     Pagination:  648-53     Citation Subset:  IM    
Department of Medicine, Faculty of Medicine, Chulalongkorn Hospital, Bangkok, Thailand.
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MeSH Terms
Aged, 80 and over
Bacteremia / drug therapy*,  microbiology
Cephalosporins / administration & dosage*,  adverse effects
Drug Administration Schedule
Follow-Up Studies
Gram-Negative Bacterial Infections / drug therapy*,  microbiology
Gram-Positive Bacterial Infections / drug therapy*,  microbiology
Middle Aged
Treatment Outcome
Reg. No./Substance:
0/Cephalosporins; 84957-29-9/cefpirome

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