| Efficacy and safety of twice-daily aclidinium bromide in COPD patients: The ATTAIN study. | |
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MedLine Citation:
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PMID: 22441743 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The efficacy and safety of two doses of aclidinium bromide were evaluated in patients with moderate to severe COPD.In this 24-week, double-blind trial, patients were randomised to twice-daily aclidinium (200 μg or 400 μg) or placebo. The primary efficacy endpoint was change in trough forced expiratory volume in 1 second (FEV1) at Week 24. Other endpoints included peak FEV1, health status (St George's Respiratory Questionnaire; SGRQ) and dyspnoea (Transitional Dyspnoea Index; TDI).Overall, 828 patients were randomised. At Week 24, significant improvements from baseline were observed with aclidinium 200 μg and 400 μg versus placebo for trough FEV1 (99 and 128 mL; both p<0.0001) and peak FEV1 (185 and 209 mL; both p<0.0001). Peak FEV1 improvements on Day 1 were comparable with Week 24. Aclidinium 200 μg and 400 μg produced significant improvements over placebo in baseline-adjusted mean SGRQ total score (-3.8 and -4.6 units; p<0.001 and <0.0001) and TDI focal score (0.6 and 1.0 units; p<0.05 and <0.001) at Week 24. With both aclidinium doses, the incidence of anticholinergic adverse events was low and similar to placebo.Twice-daily aclidinium significantly improved bronchodilation, health status and dyspnoea, and was well tolerated in patients with COPD. |
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Authors:
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Paul W Jones; Dave Singh; Eric D Bateman; Alvar Agusti; Rosa Lamarca; Gonzalo de Miquel; Rosa Segarra; Cynthia Caracta; Esther Garcia Gil |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-22 |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: - ISSN: 1399-3003 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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University of London, London, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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