| Efficacy, safety, and tolerability of isradipine in hypertension as used in general practice in a developing country (Pakistan). | |
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MedLine Citation:
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PMID: 8466727 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This open-label trial of isradipine was carried out in 3422 outpatients by 893 general practitioners to assess the efficacy, safety, and tolerability of isradipine as monotherapy in mild-to-moderate hypertension. Patients received 2.5 mg isradipine twice daily as monotherapy for 6 weeks following a placebo wash-out period of 1 week. After 6 weeks of active treatment, diastolic blood pressure was significantly reduced from 106 +/- 7.7 to 89.4 +/- 8.0 mm Hg (P < .001). Systolic blood pressure also decreased significantly, from 166.8 +/- 19.6 to 141.8 +/- 15.7 mm Hg (P < .001). Blood pressure was normalized in 75.68% of the patients. A total of 629 patients (19%) reported adverse events, 79 (2.3%) of whom withdrew from the study for this reason. The most common side-effects were headache (8.7%), palpitations/tachycardia (3.8%), vertigo (2.89%) and flushing (1.00%). In conclusion, 2.5 mg isradipine twice daily is a safe, effective, and well tolerated form of monotherapy in the treatment of hypertension in general practice in a developing country (Pakistan). |
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Authors:
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A Samad; A H Khan; M S Hashmi |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of hypertension Volume: 6 ISSN: 0895-7061 ISO Abbreviation: Am. J. Hypertens. Publication Date: 1993 Mar |
Date Detail:
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Created Date: 1993-05-10 Completed Date: 1993-05-10 Revised Date: 2009-02-24 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 54S-56S Citation Subset: IM |
Affiliation:
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Department of Cardiology, National Institute of Cardiovascular Diseases, Karachi, Pakistan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Developing Countries Family Practice Female Humans Hypertension / drug therapy* Isradipine / adverse effects, therapeutic use* Male Middle Aged Pakistan Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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75695-93-1/Isradipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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