| Efficacy and safety of tigecycline monotherapy compared with vancomycin-aztreonam in the treatment of complicated skin and skin structure infections in patients from India and Taiwan. | |
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MedLine Citation:
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PMID: 21439514 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: To compare the monotherapy of tigecycline with vancomycin-aztreonam in hospitalized patients from India and Taiwan with complicated skin and skin structure infections (cSSSIs). METHODS: Safety and efficacy data were analyzed for Indian (n = 86) and Taiwanese (n = 41) patients hospitalized with cSSSIs who participated in two international Phase 3, randomized, double-blind studies. RESULTS: Patients were treated for 5-14 days. Cure rates at the test-of-cure assessment (12-92 days post-therapy) were generally similar between tigecycline and vancomycin-aztreonam in the clinically evaluable populations (India, 83.3% vs. 75.8%; Taiwan, 78.6% vs. 90%) and in the clinical modified intent-to-treat populations (India, 78.6% vs. 66.7%; Taiwan, 73.3% vs. 75.0%). Nausea and vomiting occurred more frequently with tigecycline, but overall safety and tolerability were comparable between the two treatments. CONCLUSIONS: Tigecycline monotherapy is a safe and effective therapy for cSSSIs in geographically distinct populations in Asia. |
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Authors:
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Yin-Ching Chuang; Chia-Ming Chang; Sacchidanand Aradhya; Bheerappa Nagari; Vishwanath Pai; Nathalie Dartois; Sylvie Jouve; Angel Cooper |
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Publication Detail:
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Type: Journal Article Date: 2011-01-15 |
Journal Detail:
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Title: Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi Volume: 44 ISSN: 1995-9133 ISO Abbreviation: J Microbiol Immunol Infect Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100956211 Medline TA: J Microbiol Immunol Infect Country: England |
Other Details:
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Languages: eng Pagination: 116-24 Citation Subset: IM |
Copyright Information:
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Copyright © 2011. Published by Elsevier B.V. |
Affiliation:
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Chi Mei Medical Center, Department of Internal Medicine, Yung Kang Dist., Tainan City, Taiwan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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