Document Detail

Efficacy and safety of tarcrolimus cream 0.1% in the treatment of vitiligo.
MedLine Citation:
PMID:  19126059     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Vitiligo is an acquired, pigmentary skin disorder which is disfiguring and difficult to treat. Phototherapy and application of topical corticosteroids are most commonly prescribed. However, these therapies are often not effective and use of corticosteroids on the face may lead to cutaneous atrophy, telangiectasia, and ocular complications. OBJECTIVE: We sought to assess the efficacy of topical tacrolimus ointment in the treatment of vitiligo. METHODS: A prospective pilot study was performed of 30 patients with vitiligo. Patients were treated with tacrolimus ointment for at least 4 months. Clinical responses were documented during clinic visits, and by pretacrolimus and post-tacrolimus photography. RESULTS: Twenty-five (83.3%) patients showed some repigmentation at the end of 4 months. Patients with vitiligo for more than 5 years also responded well to tacrolimus ointment. Repigmentation in active vitiligo was superior to that in stable vitiligo. 80% of patients with segmental vitiligo of the head and neck showed some response to tacrolimus, but there was no statistical significance between segmental and vulgaris vitiligo. The mean percentage of repigmentation on the head and neck was greater than that on the trunk and extremities. Four patients initially experienced burning on application. CONCLUSIONS: Topical tacrolimus ointment is an effective and well-tolerated alternative therapy for vitiligo especially involving the head and neck.
Ai-E Xu; Di-Min Zhang; Xiao-Dong Wei; Bo Huang; Liang-Jun Lu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of dermatology     Volume:  48     ISSN:  1365-4632     ISO Abbreviation:  Int. J. Dermatol.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-07     Completed Date:  2009-05-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243704     Medline TA:  Int J Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  86-90     Citation Subset:  IM    
Department of Dermatology, the Third Hospital of Hangzhou, Hangzhou, China.
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MeSH Terms
Administration, Topical
Analysis of Variance
Dose-Response Relationship, Drug
Drug Administration Schedule
Drug Toxicity
Follow-Up Studies
Immunosuppressive Agents / adverse effects,  therapeutic use*
Pilot Projects
Prospective Studies
Severity of Illness Index
Tacrolimus / adverse effects,  therapeutic use*
Treatment Outcome
Vitiligo / diagnosis,  drug therapy*
Young Adult
Reg. No./Substance:
0/Emollients; 0/Immunosuppressive Agents; 109581-93-3/Tacrolimus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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