| Efficacy and safety of sparfloxacin in combination with kanamycin and ethionamide in multidrug-resistant pulmonary tuberculosis patients: preliminary results. | |
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MedLine Citation:
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PMID: 11409584 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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SETTING: Department of tuberculosis and chest diseases of a tertiary referral tuberculosis institute in New Delhi, India. OBJECTIVE: To study the efficacy and safety of sparfloxacin, in combination with kanamycin (for the initial 3-4 months) and ethionamide, in multidrug-resistant (MDR) pulmonary tuberculosis patients. DESIGN: Prospective, uncontrolled study of nine patients with pulmonary tuberculosis who had received adequate anti-tuberculosis treatment with first-line drugs, including supervised category II treatment regimen as per World Health Organization guidelines for 5 months, and were still sputum smear acid-fast bacilli positive. It was planned to give them kanamycin (initial 3-4 months), ethionamide and sparfloxacin for 2 years. RESULTS: All nine patients achieved sputum conversion within 6 months. Seven patients converted within 3.5 months, two of these within 1 month. All patients reported improvement in clinical symptoms, and chest X-ray improved in seven patients. Four patients developed mild to moderate phototoxicity. Eight patients have completed treatment for an average of 19 months (range 15-24 months), and are still under follow-up. One patient defaulted after 7 months of treatment. CONCLUSIONS: In MDR-TB patients, sparfloxacin, along with other anti-tuberculosis drugs, appears to be effective and safe. Mild to moderate phototoxicity is common. However, the long-term results, including relapses, are still awaited. |
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Authors:
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R Singla; S Gupta; R Gupta; V K Arora |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Volume: 5 ISSN: 1027-3719 ISO Abbreviation: Int. J. Tuberc. Lung Dis. Publication Date: 2001 Jun |
Date Detail:
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Created Date: 2001-06-18 Completed Date: 2001-11-01 Revised Date: 2013-04-24 |
Medline Journal Info:
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Nlm Unique ID: 9706389 Medline TA: Int J Tuberc Lung Dis Country: France |
Other Details:
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Languages: eng Pagination: 559-63 Citation Subset: IM |
Affiliation:
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Department of Tuberculosis and Chest Diseases, LRS Institute of Tuberculosis and Allied Diseases, New Delhi, India. lrsinet@bol.net.in |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-Infective Agents / adverse effects*, therapeutic use* Antitubercular Agents / adverse effects*, therapeutic use* Culture Media Dermatitis, Phototoxic / etiology Drug Therapy, Combination Ethionamide / adverse effects*, therapeutic use* Fluoroquinolones* Humans Kanamycin / adverse effects*, therapeutic use* Male Microbial Sensitivity Tests Middle Aged Mycobacterium tuberculosis / drug effects Prospective Studies Sputum / microbiology Tuberculosis, Multidrug-Resistant / drug therapy* Tuberculosis, Pulmonary / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents; 0/Antitubercular Agents; 0/Culture Media; 0/Fluoroquinolones; 536-33-4/Ethionamide; 59-01-8/Kanamycin; Q90AGA787L/sparfloxacin |
| Comments/Corrections | |
Comment In:
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Int J Tuberc Lung Dis. 2002 Feb;6(2):174-5; author reply 175-6
[PMID:
11931420
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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