Document Detail

Efficacy and safety of serial glycolic acid peels and a topical regimen in the treatment of recalcitrant melasma.
MedLine Citation:
PMID:  17204097     Owner:  NLM     Status:  MEDLINE    
Melasma is a common acquired disorder of facial hyperpigmentation. In this study we investigated the efficacy and safety of a combined treatment regimen including serial glycolic acid peels, topical azelaic acid cream and adapalene gel in the treatment of recalcitrant melasma. Twenty-eight patients with recalcitrant melasma were enrolled in a prospective, randomized, controlled trial lasting 20 weeks. The patients of the group receiving chemical peels underwent serial glycolic acid peels in combination with topical azelaic acid 20% cream (b.i.d.) and adapalene 0.1% gel (q.i.d., applied at night). The control group received only topical treatment including topical azelaic acid and adapalene. The clinical improvement was assessed with the Melasma Area Severity Index (MASI) at baseline and monthly during the 20-week treatment period. The results showed a prominent decrease in MASI scores at the end of the treatment in both groups, although the results were better in the group receiving chemical peels (P=0.048). All patients tolerated the topical agents well with minimal irritation observed in the first few weeks of the therapy. Three patients in the glycolic acid peel group developed a mild-degree postinflammatory hyperpigmentation with total clearance at the end of the treatment period. Therefore, the present study suggests that combined treatment with serial glycolic acid peels, azelaic acid cream and adapalene gel should be considered as an effective and safe therapy in recalcitrant melasma.
Hakan Erbil; Engin Sezer; Bülent Taştan; Ercan Arca; Zafer Kurumlu
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Journal of dermatology     Volume:  34     ISSN:  0385-2407     ISO Abbreviation:  J. Dermatol.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-05     Completed Date:  2007-03-15     Revised Date:  2013-05-24    
Medline Journal Info:
Nlm Unique ID:  7600545     Medline TA:  J Dermatol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  25-30     Citation Subset:  IM    
Department of Dermatology, Gülhane Military Medical Academy, School of Medicine, Etlik, Ankara, Turkey.
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MeSH Terms
Administration, Topical
Dermatologic Agents / administration & dosage*,  adverse effects
Dicarboxylic Acids / administration & dosage*,  adverse effects
Drug Therapy, Combination
Facial Dermatoses / therapy*
Glycolates* / adverse effects
Keratolytic Agents* / adverse effects
Melanosis / therapy*
Middle Aged
Naphthalenes / administration & dosage*,  adverse effects
Reg. No./Substance:
0/Dermatologic Agents; 0/Dicarboxylic Acids; 0/Glycolates; 0/Keratolytic Agents; 0/Naphthalenes; 123-99-9/azelaic acid; 1L4806J2QF/adapalene; 79-14-1/glycolic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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