Document Detail


Efficacy and safety of oral tocainide in refractory ventricular arrhythmia: a preliminary report on an open label study.
MedLine Citation:
PMID:  2424347     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The preliminary data on efficacy and safety of oral tocainide in refractory ventricular dysrhythmia in 8 patients is described. Two patients died; one within 15 days and the other after 1750 days of continuous tocainide therapy. The cause of death in both patients was unclear. During initial administration and acute titration, oral tocainide was extremely effective in lidocaine-sensitive ventricular dysrhythmia and in patients with Q-T prolongation syndrome. Four out of 8 patients received tocainide in presence of left ventricular dysfunction and 2 out of 4 such patients died suddenly. Minor central nervous system side effects were seen in 2 patients and dermatologic adverse reaction was seen in one patient only.
Authors:
R K Mahapatra; D Mahapatra
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Angiology     Volume:  37     ISSN:  0003-3197     ISO Abbreviation:  Angiology     Publication Date:  1986 Apr 
Date Detail:
Created Date:  1986-06-30     Completed Date:  1986-06-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  285-93     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Anti-Arrhythmia Agents / administration & dosage,  therapeutic use*,  toxicity
Arrhythmias, Cardiac / drug therapy*
Cardiac Complexes, Premature / drug therapy*
Central Nervous System Diseases / chemically induced
Clinical Trials as Topic
Drug Eruptions / etiology
Electrocardiography
Female
Humans
Lidocaine / administration & dosage,  analogs & derivatives*,  therapeutic use,  toxicity
Long QT Syndrome / drug therapy*
Male
Middle Aged
Tachycardia / drug therapy*
Tocainide
Chemical
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 137-58-6/Lidocaine; 41708-72-9/Tocainide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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