Document Detail

Efficacy and safety of nifedipine versus magnesium sulfate in the management of preterm labor: a randomized study.
MedLine Citation:
PMID:  8238157     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Our purpose was to establish the efficacy and safety of nifedipine versus magnesium sulfate in arresting preterm labor and the efficacy of nifedipine versus terbutaline in preventing recurrent labor. STUDY DESIGN: Singleton pregnancies at < 34 weeks in preterm labor were randomized to either oral nifedipine or intravenous magnesium sulfate. In case of tocolysis failure ritodrine was added. After labor was arrested, the patients in the nifedipine group were maintained on oral nifedipine, and those in the magnesium sulfate group were treated with oral terbutaline until completing 34 weeks. RESULTS: Of 100 patients 80 were considered eligible, of whom 39 were randomized to the nifedipine group. Both groups were comparable in terms of a number of entry variables, including cervical examination, contraction frequency, and gestational age. Both drugs were equally effective in arresting labor and delaying delivery > 48 hours, 92% versus 93%. Both study groups had a similar incidence of side effects, although four (10%) of magnesium sulfate-treated patients required drug discontinuation because of severe symptoms. Nifedipine was as effective as terbutaline in preventing recurrent labor, 26% versus 24%, and in achieving a gestation > 34 weeks, 62% versus 68%. CONCLUSIONS: Oral nifedipine is as effective as magnesium sulfate and terbutaline in arresting and preventing idiopathic preterm labor.
J L Glock; W J Morales
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  169     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1993-11-26     Completed Date:  1993-11-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  960-4     Citation Subset:  AIM; IM    
Orlando Regional Medical Center, Florida.
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MeSH Terms
Administration, Oral
Administration, Sublingual
Chi-Square Distribution
Infusions, Intravenous
Magnesium Sulfate / administration & dosage,  adverse effects,  therapeutic use*
Nifedipine / administration & dosage,  adverse effects,  therapeutic use*
Obstetric Labor, Premature / drug therapy*
Pregnancy Outcome
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Prospective Studies
Tocolysis / methods*
Treatment Outcome
Reg. No./Substance:
21829-25-4/Nifedipine; 7487-88-9/Magnesium Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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