Document Detail


Efficacy and safety of nicardipine for chronic, stable angina pectoris: a multicenter randomized trial.
MedLine Citation:
PMID:  3094355     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nicardipine, a new calcium channel blocking drug of the dihydropyridine family, was administered to 63 patients at a dose of 30 or 40 mg 3 times daily in a multicenter, randomized, double-blind, placebo-controlled, crossover trial. Nicardipine midly increased heart rate (HR) at rest and midly decreased the blood pressure (BP) at rest. When generally similar responses to the 30- and 40-mg doses were averaged, nicardipine produced a 7% increase in peak exercise HR, which was balanced by a 6% decrease in peak exercise BP. Thus, no change occurred in the exercise HR-BP product. With nicardipine, treadmill exercise duration increased 9%, time to angina increased 15%, time to 1-mm ST-segment depression increased 16%, and oxygen consumption at peak exercise increased 13%. Mean anginal frequency declined, as did mean weekly sublingual nitroglycerin consumption, but not significantly. There were more cardiovascular side effects with nicardipine than with placebo, with at least 3 patients having increased angina judged by investigators as probably related to the drug. Vasodilatory side effects were also more frequent with nicardipine, but were generally mild and well tolerated; the drug had to be discontinued in only 1 patient, because of vasodilatory effects. Nicardipine is effective and generally well tolerated in patients with chronic stable angina.
Authors:
S Scheidt; M M LeWinter; J Hermanovich; K Venkataraman; D Freedman
Related Documents :
22732425 - Exercise training-induced regulation of mitochondrial quality.
1937985 - Exercise cardiovascular responses to gallopamil in ischemic heart disease.
19002405 - Comparative effects of once-daily molsidomine in coronary patients from two distinct eu...
2874825 - Comparison of single doses of ketanserin and placebo in chronic stable angina.
10396565 - Surgical simulation: an animal tissue model for training in therapeutic and diagnostic ...
22460475 - Aerobic exercise alters skeletal muscle molecular responses to resistance exercise.
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The American journal of cardiology     Volume:  58     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1986 Oct 
Date Detail:
Created Date:  1986-11-07     Completed Date:  1986-11-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  715-21     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Angina Pectoris / drug therapy*
Clinical Trials as Topic
Double-Blind Method
Female
Humans
Male
Middle Aged
Nicardipine / adverse effects,  therapeutic use*
Nitroglycerin / therapeutic use
Random Allocation
Chemical
Reg. No./Substance:
55-63-0/Nitroglycerin; 55985-32-5/Nicardipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Dose-dependent thrombolysis, pharmacokinetics and hemostatic effects of recombinant human tissue-typ...
Next Document:  Comparison of acute hemodynamic effects of nitroglycerin versus diltiazem and combined acute effects...