| Efficacy and safety of multidrug therapy in paucibacillary leprosy in Singapore. | |
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MedLine Citation:
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PMID: 8341116 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A total of 49 patients with paucibacillary leprosy (PB) who completed multidrug therapy (MDT) between 1985 and 1990 were analysed retrospectively for efficacy and complications; 20 (40.8%) patients had borderline-tuberculoid (BT), 13 (26.5%) had tuberculoid (TT), 1 (2.1%) had indeterminate (I) and 15 (30.0%) had pure neural (N) leprosy; 26 patients (76.5% of 34 non-neural leprosy) were skin biopsied for histological cure before MDT was stopped. Of these 26 patients, 19 had histological clearance at 6 months while the remaining 7 cleared beyond 1 year (18-36 months). The remaining 8 non-neural patients who refused rebiopsy had MDT for 6-8 months and the MDT was stopped when there was clinical clearance. Of the 15 neural (N) leprosy patients, 11 were given MDT for 6 months while the rest had 12-18 months of treatment; 1 patient with neural leprosy, who was treated for 6 months, relapsed with BT leprosy 18 months post-treatment. There were few complications among the 49 patients-4 (8.2%) patients developed reaction to dapsone, 1 (2.0%) had the dapsone syndrome, 2 (4.1%) had haemolytic anaemia and 1 (2.0%) had dapsone hepatitis; 7 (14.3%) patients had type I reaction. |
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Authors:
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J T Lim; T Tan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Leprosy review Volume: 64 ISSN: 0305-7518 ISO Abbreviation: Lepr Rev Publication Date: 1993 Jun |
Date Detail:
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Created Date: 1993-09-01 Completed Date: 1993-09-01 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0243711 Medline TA: Lepr Rev Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 136-42 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Clofazimine / administration & dosage, adverse effects Dapsone / administration & dosage, adverse effects Drug Therapy, Combination Female Humans Leprostatic Agents / administration & dosage*, adverse effects Leprosy / drug therapy* Male Middle Aged Rifampin / administration & dosage, adverse effects |
| Chemical | |
Reg. No./Substance:
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0/Leprostatic Agents; 13292-46-1/Rifampin; 2030-63-9/Clofazimine; 80-08-0/Dapsone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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