Document Detail


Efficacy and safety of mifepristone and buccal misoprostol versus buccal misoprostol alone for medical abortion.
MedLine Citation:
PMID:  22009509     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: To evaluate the efficacy and safety of mifepristone and buccal misoprostol versus buccal misoprostol alone in medical abortion of ≤56 days. STUDY DESIGN: One hundred pregnant women having gestational age ≤56 days were randomized to group A and group B. In group A, patients received 200 mg mifepristone on day 1, followed by buccal misoprostol 800 µg on day 2, and in group B patients received 800 µg buccal misoprostol only on day 1. MAIN OUTCOME MEASURES: Complete abortion was the principal outcome measure. Secondary outcome measures were side-effects and acceptability. RESULTS: Forty-six (92%) patients in group A and 37 (74%) patients in group B aborted successfully (p value 0.017). Four (8%) patients in group A and eight (16%) patients in group B had incomplete abortion with retained products of conception. In group B, three (6%) patients had missed abortion and two (4%) patients had continued pregnancy whereas none of the patients in group A had missed abortion or continued pregnancy. The overall method acceptance was 100% whereas the overall route acceptance was 83%. CONCLUSION: Misoprostol-alone regimen is a low-cost regimen as compared to mifepristone/misoprostol regimen. Though the efficacy of mifepristone followed by buccal misoprostol is better, buccal misoprostol alone can be used for termination of pregnancy in patients where mifepristone is either unavailable or contraindicated.
Authors:
Krishna Dahiya; Kamlesh Ahuja; Atul Dhingra; Nirmala Duhan; Smiti Nanda
Related Documents :
21803529 - Deep vein thrombosis after total knee or hip arthroplasty is associated with increased ...
21572319 - Treatment with epinephrine (adrenaline) in suspected anaphylaxis during anesthesia in d...
11494619 - Maxillofacial implications and surgical treatment of arthrogryposis multiplex congenita.
21631509 - Effects of nonsurgical periodontal therapy on c-reactive protein and serum lipids in jo...
21924629 - Relationship between plethysmographic waveform changes and hemodynamic variables in ane...
21607579 - Transnasal endoscopic marsupialization of postoperative maxillary mucoceles: middle mea...
22732269 - Gastroprotective therapy does not improve outcomes of patients with helicobacter pylori...
11440349 - Tiagabine: efficacy and safety in adjunctive treatment of partial seizures.
9631969 - Elective carotid artery stenting in the presence of contralateral occlusion.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-19
Journal Detail:
Title:  Archives of gynecology and obstetrics     Volume:  -     ISSN:  1432-0711     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710213     Medline TA:  Arch Gynecol Obstet     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
, 74-R, Model Town, Rohtak, 124001, Haryana, India, krishnadahiya@rediffmail.com.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The impact of July hospital admission on outcome after surgery for spinal metastases at academic med...
Next Document:  Efficacy of transcutaneous electrical nerve stimulation for pain relief in women undergoing office e...