Document Detail

Efficacy and safety of midazolam and oxazepam in insomniacs.
MedLine Citation:
PMID:  6138067     Owner:  NLM     Status:  MEDLINE    
In a multicentre, double-blind, parallel study performed in 78 hospitalized patients who complained of mild, moderate or severe insomnia, the efficacy and safety of 15 mg midazolam were compared with those of 15 mg oxazepam, both orally administered. The results showed statistically significant better results in the onset of sleep in the patients treated with midazolam. Other sleep parameters, such as quality and duration of sleep as well as the condition of the patients on morning awakenings, were also improved in more patients treated with midazolam. Safety (clinical and biological) was very good in both groups of patients.
R Lupolover; U Ballmer; J Helcl; J Escher; B Pavletic
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  16 Suppl 1     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1983  
Date Detail:
Created Date:  1983-12-17     Completed Date:  1983-12-17     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  139S-143S     Citation Subset:  IM    
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MeSH Terms
Anti-Anxiety Agents / adverse effects,  therapeutic use*
Benzodiazepines / adverse effects,  therapeutic use*
Clinical Trials as Topic
Double-Blind Method
Middle Aged
Oxazepam / adverse effects,  therapeutic use*
Sleep Initiation and Maintenance Disorders / drug therapy*
Reg. No./Substance:
0/Anti-Anxiety Agents; 12794-10-4/Benzodiazepines; 59467-70-8/Midazolam; 604-75-1/Oxazepam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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