| Efficacy and safety of a live canine adenovirus-vectored rabies virus vaccine in swine. | |
| | |
MedLine Citation:
|
PMID: 18721839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Rabies infections in swine have been reported occasionally in recent years in certain geographic locations. Although a protective vaccine consisting of inactivated rabies virus is available for use in swine, searching for a more economically viable formulation for use in developing countries is always a priority. This work describes the testing of a canine adenovirus that expresses a rabies viral epitope (CAV-2-E3Delta-RGP) in a porcine rabies model. The data presented here show that the recombinant viral vaccine was effective in protecting swine against rabies if administered intramuscularly, but not orally or intranasally, and that protection was probably related to the development of a humoral response that lasted at least 28 weeks. Following vaccination, no behavioral abnormalities were observed in vaccinated swine and virus particles were not detected in either tissues or body fluids, indicating that this formulation was safe. The recombinant virus stimulated an effective level of antibody response in the immunized swine after a single intramuscular inoculation. |
| | |
Authors:
|
Ye Liu; Shoufeng Zhang; Guangpeng Ma; Fei Zhang; Rongliang Hu |
Related Documents
:
|
15813639 - Guillain-barre syndrome occurring after rabies vaccination. 11459009 - Characterization of in vitro and in vivo antiviral activity of lactoferrin and ribaviri... 6144829 - Failure to achieve predicted antibody responses with intradermal and intramuscular huma... 9577769 - First north american field release of a vaccinia-rabies glycoprotein recombinant virus. 4637609 - Stimulation of rabies vaccine in mice by low doses of polyadenylic:polyuridylic complex. 2480399 - Semple rabies vaccine: presence of myelin basic protein and proteolipid protein and its... 17559989 - Adenovirus-based vaccine prevents pneumonia in ferrets challenged with the sars coronav... 11682709 - Influenza vaccination coverage in elderly people, campania (italy), 1999. 7578779 - Electrochemical impedance spectroscopy of preoxidized ma 956 superalloy during in vitro... |
Publication Detail:
|
Type: Journal Article Date: 2008-08-20 |
Journal Detail:
|
Title: Vaccine Volume: 26 ISSN: 0264-410X ISO Abbreviation: Vaccine Publication Date: 2008 Oct |
Date Detail:
|
Created Date: 2008-09-15 Completed Date: 2008-11-18 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8406899 Medline TA: Vaccine Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 5368-72 Citation Subset: IM |
Affiliation:
|
Laboratory of Epidemiology, Veterinary Institute, Academy of Military Medical Science, 1068 Qinglong Road, Changchun, PR China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenoviruses, Canine
/
genetics,
immunology* Animals Antibodies, Viral / immunology Epitopes / immunology Female Genetic Vectors Injections, Intramuscular Male Mice Mice, Inbred BALB C Neutralization Tests Rabies / immunology, prevention & control*, therapy, veterinary Rabies Vaccines / administration & dosage, immunology, therapeutic use* Rabies virus / immunology* Swine / immunology, virology* Swine Diseases / immunology, prevention & control*, therapy |
| Chemical | |
Reg. No./Substance:
|
0/Antibodies, Viral; 0/Epitopes; 0/Rabies Vaccines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Influenza vaccination coverage in patients with cystic fibrosis followed at 12 care centers in the G...
Next Document: Pre-bled-young-rats in genotoxicity testing: a model for peripheral blood micronucleus assay.