Document Detail


Efficacy and safety of intravenous iron therapy as an alternative/adjunct to allogeneic blood transfusion.
MedLine Citation:
PMID:  18069918     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Anaemia is a common condition among patients admitted to hospital medicosurgical departments, as well as in critically ill patients. Anaemia is more frequently due to absolute iron deficiency (e.g. chronic blood loss) or functional iron deficiency (e.g. chronic inflammatory states), with other causes being less frequent. In addition, preoperative anaemia is one of the major predictive factors for perioperative blood transfusion. In surgical patients, postoperative anaemia is mainly caused by perioperative blood loss, and it might be aggravated by inflammation-induced inhibition of erythropoietin and functional iron deficiency (a condition that cannot be corrected by the administration of oral iron). All these mechanisms may be involved in the anaemia of the critically ill. Intravenous iron administration seems to be safe, as very few severe side-effects were observed, and may result in hastened recovery from anaemia and lower transfusion requirements. However, it is noteworthy that many of the recommendations given for intravenous iron treatment are not supported by a high level of evidence and this must be borne in mind when making decisions regarding its application to a particular patient. Nonetheless, this also indicates the need for further large, randomized controlled trials on the safety and efficacy of intravenous iron for the treatment of anaemia in different clinical settings.
Authors:
M Muñoz; C Breymann; J A García-Erce; S Gómez-Ramírez; J Comin; E Bisbe
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Publication Detail:
Type:  Journal Article; Review     Date:  2007-12-07
Journal Detail:
Title:  Vox sanguinis     Volume:  94     ISSN:  1423-0410     ISO Abbreviation:  Vox Sang.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-14     Completed Date:  2008-04-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413606     Medline TA:  Vox Sang     Country:  England    
Other Details:
Languages:  eng     Pagination:  172-83     Citation Subset:  IM    
Affiliation:
Transfusion Medicine, School of Medicine, University of Málaga, Málaga, Spain. mmunoz@uma.es
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MeSH Terms
Descriptor/Qualifier:
Anaphylaxis / etiology
Anemia, Iron-Deficiency / complications,  drug therapy*,  therapy*
Blood Transfusion*
Combined Modality Therapy
Critical Care
Female
Heart Failure / complications
Humans
Infection / etiology
Inflammatory Bowel Diseases / complications
Injections, Intravenous
Intraoperative Period
Iron / administration & dosage*,  adverse effects
Iron Overload / etiology
Kidney Failure, Chronic / complications
Neoplasms / complications
Oxidative Stress / drug effects
Postpartum Period
Pregnancy
Pregnancy Complications, Hematologic / drug therapy,  therapy
Safety
Chemical
Reg. No./Substance:
7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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