| Efficacy and safety of inhaled corticosteroids in combination with a long-acting beta2-agonist in asthmatic children under age 5. | |
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MedLine Citation:
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PMID: 15360067 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The incidence of asthma in children under age 5 is higher than in any other segment of the population. Current NAEPP guidelines recommend treatment of some asthmatics in this age group with the combination of an inhaled corticosteroid and a long-acting beta2-agonist even though this practice has never been studied with children younger than 4. This retrospective study analyzes the efficacy and safety of a combination of fluticasone propionate (FP) and salmeterol (SA) in children under 5. Fifty patients who started using FP/SA before the age of 60 months were included in the analysis. To determine efficacy, we tracked the change in emergency room visits, hospitalizations, and the frequency of wheezing as a result of treatment. Emergency room visits were reduced from 78 to 5 (p<0.001), hospitalizations were reduced from 43 to 2 (p<0.001) and frequency of wheezing, daily, weekly, or monthly, was also reduced significantly (p<0.003). In terms of safety, there was only a 3.4% reduction in height percentile (p=0.37). Combination therapy is highly efficacious and safe for asthmatics under the age of 5. A well-designed prospective study is necessary to further evaluate the benefits and risks of this treatment method. |
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Authors:
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Sudhir Sekhsaria; Mikhayl Alam; Tahir Sait; Barnaby Starr; Monica Parekh |
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Publication Detail:
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Type: Journal Article; Multicenter Study |
Journal Detail:
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Title: The Journal of asthma : official journal of the Association for the Care of Asthma Volume: 41 ISSN: 0277-0903 ISO Abbreviation: J Asthma Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-09-13 Completed Date: 2004-09-27 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8106454 Medline TA: J Asthma Country: United States |
Other Details:
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Languages: eng Pagination: 575-82 Citation Subset: IM |
Affiliation:
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Union Memorial Hospital, Baltimore, Maryland 21218, USA. asthma4@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Adrenal Cortex Hormones / administration & dosage* Adrenergic beta-Agonists / administration & dosage* Albuterol / administration & dosage*, analogs & derivatives* Androstadienes / administration & dosage* Asthma / drug therapy* Bronchodilator Agents / administration & dosage* Child, Preschool Drug Therapy, Combination Female Humans Male Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Adrenergic beta-Agonists; 0/Androstadienes; 0/Bronchodilator Agents; 18559-94-9/Albuterol; 89365-50-4/salmeterol; 90566-53-3/fluticasone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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