Document Detail


Efficacy and safety of indomethacin compared with magnesium sulfate in the management of preterm labor: a randomized study.
MedLine Citation:
PMID:  8333483     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Our purpose was to evaluate the relative efficacy and safety of indomethacin versus magnesium sulfate in the management of preterm labor in pregnancies < 32 weeks of gestation. STUDY DESIGN: Eligible patients admitted with singleton pregnancies and idiopathic preterm labor between August 1988 and October 1989 were randomized by sealed envelopes to receive either indomethacin or intravenous magnesium sulfate. RESULTS: Of 101 eligible patients 49 were randomized to receive indomethacin. The two study groups were similar in regard to a number of entry variables, including gestational age, cervical examination, and contraction frequency. Indomethacin was as effective as magnesium sulfate in delaying delivery > 48 hours, 90% versus 85%, and together with oral terbutaline in extending the gestation, 22.9 versus 22.7 days. Tocolysis with magnesium sulfate was discontinued in eight (15%) patients because of maternal side effects, in contrast to none in the indomethacin group, p < 0.05. CONCLUSION: For gestations < 32 weeks indomethacin may be considered an appropriate alternative to magnesium sulfate as a first-time tocolytic agent.
Authors:
W J Morales; H Madhav
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  169     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1993-08-19     Completed Date:  1993-08-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  97-102     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics and Gynecology, Orlando Regional Medical Center, FL.
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Humans
Indomethacin / adverse effects,  therapeutic use*
Magnesium Sulfate / adverse effects,  therapeutic use*
Obstetric Labor, Premature / drug therapy*
Pregnancy
Prospective Studies
Tocolytic Agents / adverse effects,  therapeutic use*
Chemical
Reg. No./Substance:
0/Tocolytic Agents; 53-86-1/Indomethacin; 7487-88-9/Magnesium Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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