Document Detail

Efficacy and safety of exchange transfusion as an adjunct therapy for severe Plasmodium falciparum malaria in nonimmune travelers: a 10-year single-center experience with a standardized treatment protocol.
MedLine Citation:
PMID:  19951317     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Even in circumstances where optimal antimalarial and supportive treatment is available, severe Plasmodium falciparum malaria is still associated with a significant case fatality. Although exchange transfusion (ET) has been considered as a controversial adjunct therapy, we have not encountered any case fatality since ET was introduced as a standard adjunct therapy for patients with severe malaria. STUDY DESIGN AND METHODS: In this retrospective cohort study of 25 patients with severe malaria, the efficacy and safety of ET as an adjunct to parenteral antimalarial treatment (which was implemented in our hospital starting in 1998) were evaluated and compared with 31 historical control patients who were treated with conventional parenteral antimalarial treatment in the period before ET was added to the standard of care for severe malaria (generally before 1997). RESULTS: The parasite clearance times (PCT)(25%), PCT(50%), PCT(75%) and PCT(90%) were all significantly shorter for patients treated with ET than for patients treated with parenteral quinine only. The shorter PCTs in the ET group were the result of a more rapid parasite clearance in the early phases after initiation of ET. CONCLUSION: No case fatalities were observed in the ET group. The complications that were observed with ET were more likely related either to the multiorgan dysfunction associated with severe malaria or to side effects of parenteral quinine rather than to the ET procedure. ET may be safely executed in a setting with intensive care facilities and availability of safe blood products and should be considered as a beneficial adjunct treatment to parenteral antimalarial therapy.
Perry J J van Genderen; Dennis A Hesselink; Jacob M Bezemer; Pieter J Wismans; David Overbosch
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Publication Detail:
Type:  Journal Article     Date:  2009-11-20
Journal Detail:
Title:  Transfusion     Volume:  50     ISSN:  1537-2995     ISO Abbreviation:  Transfusion     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-19     Completed Date:  2010-05-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417360     Medline TA:  Transfusion     Country:  United States    
Other Details:
Languages:  eng     Pagination:  787-94     Citation Subset:  IM    
Department of Internal Medicine, Harbour Hospital and Institute for Tropical Diseases, Erasmus MC, Rotterdam, the Netherlands.
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MeSH Terms
Antimalarials / therapeutic use
Cohort Studies
Exchange Transfusion, Whole Blood / adverse effects,  methods*,  standards
Malaria, Falciparum / drug therapy,  immunology,  therapy*
Middle Aged
Parasitemia / drug therapy,  therapy
Patient Selection
Plasmodium falciparum / isolation & purification
Quinine / therapeutic use
Retrospective Studies
Reg. No./Substance:
0/Antimalarials; 130-95-0/Quinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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