| Efficacy and safety of eletriptan 20 mg, 40 mg and 80 mg in Japanese migraineurs. | |
| | |
MedLine Citation:
|
PMID: 12133040 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This prospective multicentre, double-blind, randomized, parallel-group, placebo-controlled trial evaluated the efficacy and safety of a single dose of eletriptan 20 mg, 40 mg and 80 mg in Japanese migraineurs. A total of 402 adult Japanese migraineurs were diagnosed using International Headache Society (IHS) criteria. At 2 h after a single dose, the headache response rates of eletriptan 20 mg, 40 mg, 80 mg and placebo were 64%, 67%, 76% and 51%, respectively, with all doses significantly superior to placebo (P<0.05). Eletriptan had a statistically significant dose response for headache relief and pain-free response at 2 h post-dose (P=0.0011 and P=0.0291, respectively). Most all-causality adverse events were mild and there were no deaths or discontinuations. Saliva samples were used to assess serum eletriptan levels 2 h post-dose. Pharmacokinetic evaluations showed no clinically significant differences between Japanese and Western subjects. Eletriptan was shown to be efficacious, safe, and well tolerated in Japanese migraineurs. |
| | |
Authors:
|
|
Publication Detail:
|
Type: Clinical Trial; Clinical Trial, Phase II; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Cephalalgia : an international journal of headache Volume: 22 ISSN: 0333-1024 ISO Abbreviation: Cephalalgia Publication Date: 2002 Jul |
Date Detail:
|
Created Date: 2002-07-22 Completed Date: 2003-01-17 Revised Date: 2008-02-11 |
Medline Journal Info:
|
Nlm Unique ID: 8200710 Medline TA: Cephalalgia Country: England |
Other Details:
|
Languages: eng Pagination: 416-23 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Oral Adolescent Adult Chromatography, High Pressure Liquid Dose-Response Relationship, Drug Double-Blind Method Female Humans Indoles / administration & dosage, adverse effects*, analysis, pharmacokinetics, therapeutic use* Japan Male Middle Aged Migraine Disorders / drug therapy* Multicenter Studies as Topic Prospective Studies Pyrrolidines / administration & dosage, adverse effects*, analysis, pharmacokinetics, therapeutic use* Recurrence Saliva / chemistry Treatment Outcome Tryptamines |
| Chemical | |
Reg. No./Substance:
|
0/Indoles; 0/Pyrrolidines; 0/Tryptamines; 0/eletriptan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A prospective study of the headache phase in 32 migraine with aura patients.
Next Document: An immunocytochemical investigation of human trigeminal nucleus caudalis: CGRP, substance P and 5-HT...