Document Detail

Efficacy and safety of continuous hemodiafiltration for acute decompensated heart failure.
MedLine Citation:
PMID:  20716841     Owner:  NLM     Status:  MEDLINE    
The mortality of heart failure patients with renal insufficiency is high, and these patients tend to develop diuretic resistance. Under these conditions, continuous hemodiafiltration (CHDF) is a possible alternative volume reduction therapy to diuretics. However, its efficacy and safety are not clear. Between April 2005 and March 2008, 248 patients with acute decompensated heart failure were admitted to the CCU of Kyoto City Hospital. Of those patients, 31 (20 volume overloaded heart failure, 11 cardiogenic shock) received CHDF therapy, and their weight loss, acute hemodynamic changes, and clinical outcome were assessed to evaluate the efficacy and safety of CHDF therapy. CHDF was performed for 6.5 +/- 6.5 days. There was no significant change in acute hemodynamics after CHDF initiation. In the volume overloaded heart failure (VH) group, significant weight loss was observed at 24 hours and 48 hours after CHDF initiation (P < 0.001). In-hospital mortality of the VH group and cardiogenic shock (CS) group were 10.0% and 54.5%, respectively. CHDF for acute decompensated heart failure (ADHF) is a safe, effective, and reliable volume reduction therapy for volume overloaded heart failure. Further investigation is required to assess the effectiveness of CHDF for cardiogenic shock.
Hiroki Shiomi; Kinya Matsubara; Makoto Ariyoshi; Yumi Iwamura; Kensuke Fukui; Tomoko Sakamoto; Takayoshi Sawanishi; Masami Shima; Keizo Furukawa
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International heart journal     Volume:  51     ISSN:  1349-2365     ISO Abbreviation:  Int Heart J     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-08-18     Completed Date:  2010-12-10     Revised Date:  2010-12-15    
Medline Journal Info:
Nlm Unique ID:  101244240     Medline TA:  Int Heart J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  247-51     Citation Subset:  IM    
Department of Cardiology, Kyoto City Hospital, Nakagyo-ku, Kyoto, Japan.
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MeSH Terms
Aged, 80 and over
Blood Pressure
Cohort Studies
Heart Failure / complications,  mortality,  therapy*
Hospital Mortality
Middle Aged
Retrospective Studies
Shock, Cardiogenic / etiology,  mortality,  therapy*
Treatment Outcome
Weight Loss
Erratum In:
Int Heart J. 2010;51(5):370

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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