Document Detail

Efficacy and safety of combined diclofenac 0.1% and gentamicin 0.3% eyedrops after phacoemulsification.
MedLine Citation:
PMID:  9278797     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To study the efficacy of combined diclofenac 0.1% and gentamicin 0.3% (Digen) eyedrops to treat postoperative inflammation and prevent ocular infection in eyes having phacoemulsification. SETTING: Department of Ophthalmology, University of Milan, San Paolo Hospital, Milan; Eye Clinic, University of Verona; and Department of Ophthalmology, University of Palermo, Italy. METHODS: This double-masked, randomized, clinical trial comprised 90 patients; 45 received Digen and 45, gentamicin 0.3% eyedrops. The main outcome measure of the study was the reduction in signs and symptoms of inflammation, graded on a four-point scale. Also assessed were the presence of bacteria in the conjunctival swab and the proportion of patients requiring additional medication. RESULTS: Digen was more effective in reducing postoperative inflammation than gentamicin alone (P < .01). No statistically significant between-group difference was found regarding antibacterial activity. Both treatments were well tolerated throughout the study. CONCLUSION: Digen seemed to maintain the properties and activities of each individual drug, making it a promising treatment for reducing inflammation after phacoemulsification.
L Rossetti; R Bellucci; S Cillino; D Monreale; L Bonomi; F Ponte; N Orzalesi
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cataract and refractive surgery     Volume:  23     ISSN:  0886-3350     ISO Abbreviation:  J Cataract Refract Surg     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-10-14     Completed Date:  1997-10-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8604171     Medline TA:  J Cataract Refract Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  745-9     Citation Subset:  IM    
Eye Clinics of the Institute of Biomedical Sciences, San Paolo Hospital, Milan, Italy.
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MeSH Terms
Administration, Topical
Aged, 80 and over
Anti-Bacterial Agents / administration & dosage,  therapeutic use*
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage,  therapeutic use*
Diclofenac / administration & dosage,  therapeutic use*
Double-Blind Method
Drug Therapy, Combination
Endophthalmitis / drug therapy*,  etiology
Eye Infections, Bacterial / drug therapy*,  etiology
Gentamicins / administration & dosage,  therapeutic use*
Middle Aged
Ophthalmic Solutions
Phacoemulsification / adverse effects*
Retrospective Studies
Treatment Outcome
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Gentamicins; 0/Ophthalmic Solutions; 15307-86-5/Diclofenac

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