Document Detail


Efficacy and safety of cilazapril, a new angiotensin-converting enzyme inhibitor.
MedLine Citation:
PMID:  2970856     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cilazapril (CIL), a new angiotensin-converting enzyme inhibitor, was evaluated for 16 weeks in 29 patients with mild to moderate essential hypertension (diastolic pressure 95 mm Hg to 115 mm Hg). Twenty-four patients (83%) normalized their blood pressure (BP) (diastolic pressure less than 90 mm Hg), 11 with low-dose CIL, six with high-dose CIL, one with high-dose CIL plus low-dose thiazide, and six with high-dose CIL and high-dose thiazide. Three withdrew because of side effects (fatigue, bloating, and polyuria). Statistically significant reductions in sitting and standing systolic and diastolic pressures occurred at 8 and 16 weeks on CIL. There was no change in standing or sitting heart rate, white blood cell count, creatinine clearance, urine protein levels. This is the first long-term data on this new converting enzyme inhibitor in human beings.
Authors:
R C Goldszer; R Rodriguez; H S Solomon
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of hypertension     Volume:  1     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1988-10-19     Completed Date:  1988-10-19     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  300S-302S     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
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MeSH Terms
Descriptor/Qualifier:
Aldosterone / blood,  urine
Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
Benzothiadiazines
Blood Pressure
Cilazapril
Diuretics
Drug Therapy, Combination
Female
Humans
Hypertension / blood,  drug therapy*,  physiopathology
Male
Pyridazines / adverse effects,  standards,  therapeutic use*
Renin / blood
Sodium Chloride Symporter Inhibitors / therapeutic use
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Benzothiadiazines; 0/Diuretics; 0/Pyridazines; 0/Sodium Chloride Symporter Inhibitors; 52-39-1/Aldosterone; 92077-78-6/Cilazapril; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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