| Efficacy and safety of central compartment neck dissection for recurrent thyroid carcinoma. | |
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MedLine Citation:
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PMID: 22249626 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: To explore the safety and efficacy of central compartment neck dissection (CCND) in the treatment of well-differentiated thyroid carcinoma (WDTC) recurrences in the central compartment of the neck. DESIGN: Retrospective medical chart review. SETTING: Tertiary-care academic hospital. PATIENTS: Eighty-two consecutively treated patients with recurrent WDTC, with a median follow-up of 28 months. MAIN OUTCOME MEASURES: Postoperative complications, disease control posttreatment, and normalization of serum thyroglobulin (Tg) level. RESULTS: Eighty-two patients underwent 86 central compartment procedures. Only CCND was performed in 36 patients (42%), while a lateral neck dissection was also required in the remainder. Postoperative hypoparathyroidism was temporary in 17 patients (20%) and permanent in 6 patients (7%). Postoperative intact serum parathyroid hormone level was greater than 15.0 pg/mL (to convert to nanograms per liter, multiply by 1.0) in 81% of patients, accurately predicting eucalcemia postoperatively. Unilateral recurrent laryngeal nerve injury was transient in 3 patients (2% of nerves at risk) and permanent in 3 patients (2%). Seventeen patients (21%) experienced subsequent recurrences after their CCND-2 patients (2%) had recurrence in the central neck, 8 (9%) in the lateral neck, 2 (2%) in the central and lateral neck, and 7 (8%) at distant sites. Twenty-seven patients underwent a CCND alone and were deemed appropriate for efficacy analysis. The Tg level was normalized in 15 patients (56%) in the group overall. Normalization occurred in 10 of the 20 patients (50%) who received sodium iodide I 131 ablation and in 5 of the 7 patients (71%) who did not. CONCLUSION: Central compartment neck dissection is a safe and efficacious procedure for the management of central neck recurrences in WDTC. |
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Authors:
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Manish D Shah; Luke D Harris; Ramez G Nassif; Dae Kim; Spiro Eski; Jeremy L Freeman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of otolaryngology--head & neck surgery Volume: 138 ISSN: 1538-361X ISO Abbreviation: Arch. Otolaryngol. Head Neck Surg. Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8603209 Medline TA: Arch Otolaryngol Head Neck Surg Country: United States |
Other Details:
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Languages: eng Pagination: 33-7 Citation Subset: AIM; IM |
Affiliation:
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FRCSC, Department of Otolaryngology-Head & Neck Surgery, Mount Sinai Hospital, 600 University Ave, Ste 401, Toronto, ON M5G 1X5, Canada. JFreeman@mtsinai.on.ca. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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