Document Detail

Efficacy and safety of caspofungin therapy in elderly patients with proven or suspected invasive fungal infections.
MedLine Citation:
PMID:  18324427     Owner:  NLM     Status:  MEDLINE    
Invasive fungal infections (IFIs) are serious complications in elderly adults. Caspofungin may provide a useful therapeutic option for elderly patients with or at high risk for IFIs. We retrospectively compared efficacy and safety outcomes in elderly (> or = 65 years of age) and non-elderly patients in three clinical trials of caspofungin: a double-blind, randomized trial versus amphotericin B for documented invasive candidiasis (IC); an open-label, non-comparative study of definite or probable invasive aspergillosis (IA); and a double-blind, randomized trial versus liposomal amphotericin B as empirical therapy (ET) in febrile neutropenic patients. A total of 159 elderly patients with a median age of 71 years (range, 65-84) received caspofungin in these studies. The median duration of caspofungin therapy was 12 days for IC and ET, and 28 days for IA. Point estimates for the favorable response rates to caspofungin were numerically higher in elderly versus non-elderly patients with IC (83% vs. 68%) or IA (64% vs. 44%) and were similar in patients receiving ET (36% vs. 34%). Adverse events related to caspofungin occurred in generally similar proportions of elderly versus non-elderly patients with IC (clinical, 33% vs. 27%; laboratory, 17% vs. 29%), with IA (clinical, 7% vs. 13%; laboratory, 13% vs. 14%), or receiving ET (clinical, 47% vs. 47%; laboratory, 24% vs. 22%). Nephrotoxicity and infusion-related toxicity developed in comparable proportions of elderly and non-elderly caspofungin recipients in all three studies. In this post-hoc analysis, caspofungin appeared to be as efficacious and well tolerated in elderly patients as in non-elderly patients.
M J Dinubile; K M Strohmaier; R J Lupinacci; A R Meibohm; C A Sable; N A Kartsonis
Related Documents :
12528327 - Severe electrolyte disturbances and renal failure in elderly patients with combined diu...
9158257 - Logistics of performing an ophthalmic assessment in elderly inpatients.
3679727 - Staff attitude changes after environmental changes on a ward for psychogeriatric patients.
1643917 - Results of coronary angioplasty in patients aged 75 years and older.
1977577 - Outcome of intervention with or without low dose oral interferon alpha in thirty-two hi...
22423427 - Quality of life in patients with cleft lip and palate after operation.
Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2008-03-07
Journal Detail:
Title:  European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology     Volume:  27     ISSN:  0934-9723     ISO Abbreviation:  Eur. J. Clin. Microbiol. Infect. Dis.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-30     Completed Date:  2008-12-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804297     Medline TA:  Eur J Clin Microbiol Infect Dis     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  663-70     Citation Subset:  IM    
Merck Research Laboratories, West Point, PA, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antifungal Agents / adverse effects,  therapeutic use*
Echinocandins / adverse effects,  therapeutic use*
Treatment Outcome
Reg. No./Substance:
0/Antifungal Agents; 0/Echinocandins; 0/caspofungin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Degenerative lumbar spinal stenosis: correlation with Oswestry Disability Index and MR imaging.
Next Document:  Pyrosequencing analysis of the gyrB gene to differentiate bacteria responsible for diarrheal disease...