Document Detail

Efficacy and safety of blue-light scleral cross-linking.
MedLine Citation:
PMID:  18811124     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate the efficacy of blue-light scleral cross-linking as well as its safety in preventing retinal damage beneath the treated sclera. METHODS: Six rabbits were unilaterally treated with topical riboflavin (0.5%) and blue light (465 nm) on the equatorial sclera using a light emitting diode source with an exposure area of 9 mm in diameter. Four weeks after the treatment, the animals were euthanized and the exposed sclera and contralateral eye sclera excised for comparative testing of biomechanical rigidity and histologic retinal cellular damage. Extensiometry was performed to evaluate the stress-strain curve of treated versus untreated sclera, and light microscopy of the treated sclera and underlying retina were also comparatively evaluated. RESULTS: Blue-light scleral cross-linking showed a three-fold increased stiffening in all tested animals in the stress-strain curve. Histological investigation revealed no retinal damage in any of the treated eyes. CONCLUSIONS: Scleral cross-linking with riboflavin and blue light (465 nm) has a stiffening effect on the sclera without histological tissue damage to the retina.
Hans Peter Iseli; Eberhard Spoerl; Peter Wiedemann; Ronald R Krueger; Theo Seiler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of refractive surgery (Thorofare, N.J. : 1995)     Volume:  24     ISSN:  1081-597X     ISO Abbreviation:  J Refract Surg     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-24     Completed Date:  2008-10-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9505927     Medline TA:  J Refract Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S752-5     Citation Subset:  IM    
IROC - Institute of Refractive and Ophthalmic Surgery, Zurich, Switzerland.
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MeSH Terms
Collagen / metabolism*
Photochemotherapy / methods*
Photosensitizing Agents / therapeutic use*,  toxicity
Retina / drug effects,  pathology
Riboflavin / therapeutic use*,  toxicity
Sclera / drug effects*,  metabolism,  radiation effects
Reg. No./Substance:
0/Photosensitizing Agents; 83-88-5/Riboflavin; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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