Document Detail

Efficacy and safety of azelaic acid and glycolic acid combination therapy compared with tretinoin therapy for acne.
MedLine Citation:
PMID:  9737831     Owner:  NLM     Status:  MEDLINE    
We conducted a 12-week, multicenter, randomized, double-masked, parallel-group study of the efficacy, safety, and tolerability of azelaic acid 20% cream and glycolic acid lotion compared with tretinoin 0.025% cream and a vehicle lotion to treat mild-to-moderate facial acne vulgaris. Patients treated with azelaic/glycolic acid experienced a significantly greater reduction in the number of papules, as well as a greater reduction in the number of inflammatory lesions, than those treated with tretinoin. Overall global improvement was approximately 25% in both groups. In the physician evaluations, treatment with azelaic/glycolic acid was found to cause significantly less dryness, scaling, and erythema than tretinoin. Patients also reported significantly less dryness, redness, and peeling with azelaic/glycolic acid. Significantly more patients in the azelaic/glycolic acid group than the tretinoin group reported that they felt attractive. The combination of azelaic acid and glycolic acid is a useful alternative to tretinoin, being at least as efficacious as the latter, while offering a superior tolerability and patient approval profile.
M C Spellman; S H Pincus
Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical therapeutics     Volume:  20     ISSN:  0149-2918     ISO Abbreviation:  Clin Ther     Publication Date:    1998 Jul-Aug
Date Detail:
Created Date:  1998-11-18     Completed Date:  1998-11-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7706726     Medline TA:  Clin Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  711-21     Citation Subset:  IM    
University of California at San Diego and VA Medical Center, USA.
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MeSH Terms
Acne Vulgaris / drug therapy*
Administration, Topical
Dermatologic Agents / adverse effects,  therapeutic use*
Dicarboxylic Acids / adverse effects,  therapeutic use*
Double-Blind Method
Glycolates / adverse effects,  therapeutic use*
Keratolytic Agents / adverse effects,  therapeutic use*
Treatment Outcome
Tretinoin / adverse effects,  therapeutic use*
Reg. No./Substance:
0/Dermatologic Agents; 0/Dicarboxylic Acids; 0/Glycolates; 0/Keratolytic Agents; 0/Ointments; 123-99-9/azelaic acid; 302-79-4/Tretinoin; 79-14-1/glycolic acid

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