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Efficacy and safety of azathioprine and dapsone as an adjuvant in the treatment of bullous pemphigoid.
MedLine Citation:
PMID:  21497011     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Bullous pemphigoid is a chronic, blistering and autoimmune disease, common in old age. The treatment usually includes systemic steroids, however, these cause high morbidity rates, and then different products that function as adjuvants have been tried. At present, there are no studies to determine which adjuvant offers a better efficacy and safety profile. METHODS: We performed a retrospective study which included the records of patients with bullous pemphigoid, treated either with azathioprine or dapsone. We evaluated the time to achieve complete remission, the time to inhibit disease progression, and the control of pruritus. RESULTS: Fifteen records of patients were selected, eight (53%) treated with azathioprine and seven (47%) with dapsone. Complete remission was achieved at week six in both groups. We found no difference in the inhibition of disease progression (p=0.083). Pruritus was controlled at four weeks of treatment in both treatments. CONCLUSIONS: Both products are effective as adjuvant in the treatment of bullous pemphigoid, with an acceptable safety profile.
Authors:
A Tirado-Sánchez; V Díaz-Molina; R M Ponce-Olivera
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-13
Journal Detail:
Title:  Allergologia et immunopathologia     Volume:  -     ISSN:  1578-1267     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370073     Medline TA:  Allergol Immunopathol (Madr)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2010 SEICAP. Published by Elsevier Espana. All rights reserved.
Affiliation:
Servicio de Dermatología, Hospital General de México, Mexico City, Mexico.
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