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Efficacy and safety of antiviral therapy in patients with Crohn's disease and chronic hepatitis C.
MedLine Citation:
PMID:  18616645     Owner:  NLM     Status:  Publisher    
Background Efficacy and safety of antiviral combination therapy in patients with Crohn;s disease (CD) and chronic hepatitis C (CHC) is presently not established and consequently CHC is rarely treated in CD patients. Aim This report analyzes the efficacy and tolerability of antiviral IFN/ribavirin therapy in patients with CHC and CD. Methods Eleven HCV infected CD patients received either 3x1.5 mug/kg/week interferon alpha-2b or 180mug/week peginterferon alpha-2a (PEGASYS((R)), Roche, Basel, CH) as monotherapy (N=1) or in combination with 800-1200 mg/d ribavirin (COPEGUS((R)), Roche, Basel, CH) (N=10) for 24 to 54 weeks according to HCV-genotype and initial response, respectively. Eight patients were under CD specific therapy. Results: Five (46%) patients (HCV-1: N=3, HCV-2: N=0, HCV-3: N=1, unknown: N=1) achieved a sustained virologic response, 3 (27%) patients relapsed, 3 (27%) were non responders (all GT 1b). At baseline the Harvey Bradshaw Index was 0 [0-8] (median [range]), increased on antiviral therapy to 4 [1-15] (p=0.005) and decreased to baseline level 0 [0-6] after 6 months follow-up. Conclusion: This preliminary experience demonstrates that treatment of CHC in patients with CD is comparable to those without CD. However, gastrointestinal symptoms may be temporarily exacerbated and haemopoietic growth factors may be required.
T-M Scherzer; K Staufer; G Novacek; P Steindl-Munda; S Schumacher; H Hofer; P Ferenci; H Vogelsang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2008-6-26
Journal Detail:
Title:  Alimentary pharmacology & therapeutics     Volume:  -     ISSN:  1365-2036     ISO Abbreviation:  Aliment. Pharmacol. Ther.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-7-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8707234     Medline TA:  Aliment Pharmacol Ther     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Medical University of Vienna, Internal Medicine III, Dept. of Gastroenterology and Hepatology, Vienna, Austria.
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