Document Detail

Efficacy and safety of aliskiren-based dual and triple combination therapies in US minority patients with stage 2 hypertension.
MedLine Citation:
PMID:  21414565     Owner:  NLM     Status:  In-Data-Review    
Minority patients with hypertension generally require combination therapy to reach blood pressure (BP) goals. We examined the BP-lowering efficacy and safety of combination aliskiren/amlodipine therapy in self-identified minority patients in the United States with stage 2 hypertension and the impact of adding hydrochlorothiazide (HCTZ) to this combination. In this 8-week double-blind study, 412 patients were randomized to receive aliskiren/amlodipine (150/5 mg) or amlodipine (5 mg) with forced titration up to aliskiren/amlodipine/HCTZ (300/10/25 mg) or aliskiren/amlodipine (300/10 mg), respectively. Overall, mean age was 55.2 years, mean body mass index was 32 kg/m(2), 62.3% were black, 28.2% were Hispanic/Latino, and 69.1% had metabolic syndrome. Mean sitting systolic blood pressure (MSSBP), the primary efficacy outcome, was reduced from 167.1 mm Hg at baseline to 130.7 mm Hg at week 8 with aliskiren/amlodipine/HCTZ and from 167.4 mm Hg to 137.9 mm Hg with aliskiren/amlodipine (P < .0001 between groups). At week 8, BP goal (<140/90 mm Hg) was achieved in 72.6% and 53.2% of patients in the two treatment groups, respectively (P < .0001). Adverse events were experienced by 34.2% and 40.2%, respectively. Combination aliskiren/amlodipine therapy was effective in treating these high-risk patients but inclusion of HCTZ provided greater antihypertensive efficacy. Both treatments were similarly well tolerated.
Keith C Ferdinand; Richard Weitzman; Marc Israel; Joleen Lee; Das Purkayastha; Edgar A Jaimes
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Society of Hypertension : JASH     Volume:  5     ISSN:  1933-1711     ISO Abbreviation:  J Am Soc Hypertens     Publication Date:    2011 Mar-Apr
Date Detail:
Created Date:  2011-03-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101312518     Medline TA:  J Am Soc Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  102-13     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American Society of Hypertension. Published by Elsevier Inc. All rights reserved.
Emory University, Atlanta, GA.
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