| Efficacy and safety of aliskiren-based dual and triple combination therapies in US minority patients with stage 2 hypertension. | |
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MedLine Citation:
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PMID: 21414565 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Minority patients with hypertension generally require combination therapy to reach blood pressure (BP) goals. We examined the BP-lowering efficacy and safety of combination aliskiren/amlodipine therapy in self-identified minority patients in the United States with stage 2 hypertension and the impact of adding hydrochlorothiazide (HCTZ) to this combination. In this 8-week double-blind study, 412 patients were randomized to receive aliskiren/amlodipine (150/5 mg) or amlodipine (5 mg) with forced titration up to aliskiren/amlodipine/HCTZ (300/10/25 mg) or aliskiren/amlodipine (300/10 mg), respectively. Overall, mean age was 55.2 years, mean body mass index was 32 kg/m(2), 62.3% were black, 28.2% were Hispanic/Latino, and 69.1% had metabolic syndrome. Mean sitting systolic blood pressure (MSSBP), the primary efficacy outcome, was reduced from 167.1 mm Hg at baseline to 130.7 mm Hg at week 8 with aliskiren/amlodipine/HCTZ and from 167.4 mm Hg to 137.9 mm Hg with aliskiren/amlodipine (P < .0001 between groups). At week 8, BP goal (<140/90 mm Hg) was achieved in 72.6% and 53.2% of patients in the two treatment groups, respectively (P < .0001). Adverse events were experienced by 34.2% and 40.2%, respectively. Combination aliskiren/amlodipine therapy was effective in treating these high-risk patients but inclusion of HCTZ provided greater antihypertensive efficacy. Both treatments were similarly well tolerated. |
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Authors:
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Keith C Ferdinand; Richard Weitzman; Marc Israel; Joleen Lee; Das Purkayastha; Edgar A Jaimes |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the American Society of Hypertension : JASH Volume: 5 ISSN: 1933-1711 ISO Abbreviation: J Am Soc Hypertens Publication Date: 2011 Mar-Apr |
Date Detail:
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Created Date: 2011-03-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101312518 Medline TA: J Am Soc Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 102-13 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 American Society of Hypertension. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Emory University, Atlanta, GA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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