Document Detail


Efficacy and safety of Meriva, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients.
MedLine Citation:
PMID:  21194249     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
In a previous three-month study of Meriva, a proprietary curcumin-phosphatidylcholine phytosome complex, decreased joint pain and improvement in joint function were observed in 50 osteoarthritis (OA) patients. Since OA is a chronic condition requiring prolonged treatment, the long-term efficacy and safety of Meriva were investigated in a longer (eight months) study involving 100 OA patients. The clinical end points (Western Ontario and McMaster Universities [WOMAC] score, Karnofsky Performance Scale Index, and treadmill walking performance) were complemented by the evaluation of a series of inflammatory markers (interleukin [IL]-1beta, IL-6, soluble CD40 ligand [sCD40L], soluble vascular cell adhesion molecule (sVCAM)-1, and erythrocyte sedimentation rate [ESR]). This represents the most ambitious attempt, to date, to evaluate the clinical efficacy and safety of curcumin as an anti-inflammatory agent. Significant improvements of both the clinical and biochemical end points were observed for Meriva compared to the control group. This, coupled with an excellent tolerability, suggests that Meriva is worth considering for the long-term complementary management of osteoarthritis.
Authors:
Giovanni Appendino; Gianni Belcaro; Maria Rosaria Cesarone; Mark Dugall; Luciano Pellegrini; Andrea Ledda; Maria Giovanna Grossi; Stefano Togni
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Alternative medicine review : a journal of clinical therapeutic     Volume:  15     ISSN:  1089-5159     ISO Abbreviation:  Altern Med Rev     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2011-01-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9705340     Medline TA:  Altern Med Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  337-44     Citation Subset:  K    
Affiliation:
Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Universita del Piemonte Orientale, Novara, Italy. Correspondence address: Universita del Piemonte Orientale, Dipartimento di Scienze Chimiche Alimentari, Farmaceutiche e Farmacologiche, Via Bovio, 6 - 28100 Novara, Italy. Email: appendino@pharm.unipmn.it.
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