| Efficacy and safety of 3-day azithromycin versus 5-day moxifloxacin for the treatment of acute bacterial exacerbations of chronic bronchitis. | |
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MedLine Citation:
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PMID: 17189096 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Antibiotic therapy is of clinical benefit in certain patients with acute exacerbations of chronic bronchitis (AECB). In this randomised, investigator-blinded, multicentre trial, azithromycin (500mg once a day (qd) for 3 days) was compared with moxifloxacin (400mg qd for 5 days) for the treatment of outpatients with AECB (forced expiratory volume in 1s (FEV(1)) >35%). Of 342 patients randomised to either treatment, 169 received azithromycin and 173 received moxifloxacin. The mean age in the azithromycin and moxifloxacin groups was 56.4 years and 55.5 years, respectively. In the intent-to-treat analysis, clinical success rates for azithromycin and moxifloxacin were comparable at Days 10-12 (90% versus 90%, respectively) and Days 22-26 (81% versus 82%, respectively). Among patients who were culture-positive at baseline for Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis or Haemophilus parainfluenzae, clinical efficacy for azithromycin versus moxifloxacin at Days 10-12 was 93% versus 84%, respectively, and at Days 22-26 it was 89% versus 73%, respectively. The incidence of at least one treatment-related adverse event (AE) in the azithromycin and moxifloxacin groups was 18.3% and 19.1%, respectively. The most common AEs were diarrhoea, nausea, abdominal pain and vaginitis. Most treatment-related AEs were of mild or moderate severity, with no serious treatment-related AEs. One subject in the moxifloxacin group discontinued treatment owing to a treatment-related AE (precordial pain and dry throat). Compliance with both regimens was >90%. Three-day azithromycin and 5-day moxifloxacin demonstrate comparable efficacy and safety for the treatment of AECB in outpatients. |
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Authors:
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Marcus Zervos; Fernando J Martinez; Guy W Amsden; Constance D Rothermel; Glenda Treadway |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of antimicrobial agents Volume: 29 ISSN: 0924-8579 ISO Abbreviation: Int. J. Antimicrob. Agents Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2006-12-25 Completed Date: 2007-03-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9111860 Medline TA: Int J Antimicrob Agents Country: Netherlands |
Other Details:
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Languages: eng Pagination: 56-61 Citation Subset: IM |
Affiliation:
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Henry Ford Hospital, Detroit, MI 48202, USA. mzervos1@hfhs.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abdominal Pain
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chemically induced Adult Aged Anti-Bacterial Agents / adverse effects, pharmacology, therapeutic use Aza Compounds / adverse effects, pharmacology, therapeutic use* Azithromycin / adverse effects, pharmacology, therapeutic use* Bronchitis, Chronic / drug therapy*, microbiology Drug Administration Schedule Female Haemophilus influenzae / drug effects, isolation & purification Haemophilus parainfluenzae / drug effects, isolation & purification Humans Male Microbial Sensitivity Tests Middle Aged Moraxella (Branhamella) catarrhalis / drug effects, isolation & purification Nausea / chemically induced Patient Compliance Quinolines / adverse effects, pharmacology, therapeutic use* Single-Blind Method Streptococcus pneumoniae / drug effects, isolation & purification Treatment Outcome Vaginitis / chemically induced |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Aza Compounds; 0/Quinolines; 0/moxifloxacin; 83905-01-5/Azithromycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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