Document Detail


Efficacy and safety of 10-deazaaminopterin in the treatment of rheumatoid arthritis. A one-year continuation, double-blind study.
MedLine Citation:
PMID:  1445448     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine the long-term safety and efficacy of 10-deazaaminopterin (10-DAM) in the treatment of rheumatoid arthritis (RA). METHODS: A 1-year continuation of an initial 15-week randomized, double-blind clinical trial of 10-DAM and methotrexate (MTX). RESULTS: 10-DAM (n = 10) and MTX (n = 8) had comparable safety and efficacy profiles. One 10-DAM-treated and 2 MTX-treated patients experienced transient side effects; 1 MTX-treated patient experienced recurrent nausea and discontinued MTX. CONCLUSION: 10-DAM appears to be as beneficial and as safe as MTX for the treatment of RA.
Authors:
G S Alarc?n; O Casta?eda; M Ferr?ndiz; C L Krumdieck; W J Koopman
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  35     ISSN:  0004-3591     ISO Abbreviation:  Arthritis Rheum.     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1992-12-07     Completed Date:  1992-12-07     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1318-21     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, University of Alabama, Birmingham 35294.
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MeSH Terms
Descriptor/Qualifier:
Adult
Alkaline Phosphatase / blood
Aminopterin / adverse effects,  analogs & derivatives*,  therapeutic use
Arthritis, Rheumatoid / blood,  drug therapy*,  physiopathology
Aspartate Aminotransferases / blood
Double-Blind Method
Female
Folic Acid / analogs & derivatives
Humans
Male
Methotrexate / adverse effects,  therapeutic use
Middle Aged
Grant Support
ID/Acronym/Agency:
AI-18745/AI/NIAID NIH HHS; AI-18958/AI/NIAID NIH HHS; AR-0355/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
52454-37-2/10-deazaaminopterin; 54-62-6/Aminopterin; 59-05-2/Methotrexate; 59-30-3/Folic Acid; EC 2.6.1.1/Aspartate Aminotransferases; EC 3.1.3.1/Alkaline Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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