Document Detail

Efficacy of routine fetal ultrasound screening for congenital heart disease in Isère County, France.
MedLine Citation:
PMID:  10327135     Owner:  NLM     Status:  MEDLINE    
Recent literature has revealed different percentages of prenatal detection of congenital heart disease. Therefore we chose to analyse the sensitivity of this screening in Isère county and to scrutinize to which extent factors like severity of the anomaly, extracardiac anomalies and maternal age influence the sensitivity. This retrospective study covers the period from 1989 to 1995. All the pregnancies with congenital heart disease in Isère county in France were reviewed and analysed, which was possible thanks to our registry of congenital anomalies. In this period, 316 cases were registered in the central database. We obtained an overall sensitivity of 34.8 per cent. By splitting the different malformations into two groups we got a detection rate of 53.7 per cent for major malformations and 26.7 per cent for other abnormalities. This difference is significant. Nevertheless, the sensitivity remains quite low. This result stresses the need for better education of investigators in primary care units, particularly because the prenatal diagnosis of congenital heart disease has a major impact on the outcome of pregnancy, which can be seen in the increased number of abortions in this group.
S K Klein; C Cans; E Robert; P S Jouk
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  19     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-06-25     Completed Date:  1999-06-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  318-22     Citation Subset:  IM    
Fédération Génétique Reproduction Développement, Centre Hospitalier de Grenoble, France.
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MeSH Terms
Coronary Vessel Anomalies / ultrasonography
Fetal Diseases / ultrasonography
Gestational Age
Heart Defects, Congenital / ultrasonography*
Heart Septal Defects / ultrasonography
Heart Ventricles / abnormalities
Maternal Age
Retrospective Studies
Sensitivity and Specificity
Ultrasonography, Prenatal*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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