Document Detail

Efficacy of red clover isoflavones in the menopausal rabbit model.
MedLine Citation:
PMID:  18973881     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the effectiveness of phytoestrogens as alternatives for selective dysfunctional changes in the menopausal rabbit model. DESIGN: Prospective, vehicle-controlled experimental study. SETTING: Reproductive pharmacology laboratory in a university department. ANIMAL(S): Twenty-four rabbits with experimentally induced menopause and six intact controls. INTERVENTION(S): Surgical menopause was induced in 24 rabbits by ovariectomy. After 4 weeks of convalescence, three groups (n = 6) were given 100 microg/kg E(2) valerate, 100 microg/kg daidzein, or 6.68 mg/kg red clover extract daily for 12 weeks. The remaining six rabbits served as the operated control group. MAIN OUTCOME MEASURE(S): Vaginal blood flow using Doppler flowmetry, before, during, and after pelvic nerve stimulation; and measured parameters of uterine weight, femoral bone density, clitoral cavernosal histology, and hormone levels. RESULT(S): After pelvic nerve stimulation, blood flow increased remarkably in the daidzein-treated group. Serum E(2) and uterine weight increased significantly in the estrogen group. Cavernosal structure was well preserved in all three treatment groups, and bone mineral density was lowest in ovariectomized controls (0.3467 g/cm(2)) and highest in the red clover (0.4012 g/cm(2)) groups. CONCLUSION(S): Supplementing isoflavones for menopause leads to significant improvements in bone density, tissue integrity, and vaginal blood flow with minimal effect on uterine weight and may therefore be a viable alternative to conventional regimens using synthetic estrogens.
P Ganesan Adaikan; B Srilatha; Amanda J Wheat
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-10-29
Journal Detail:
Title:  Fertility and sterility     Volume:  92     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-07     Completed Date:  2010-01-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2008-13     Citation Subset:  IM    
Department of Obstetrics and Gynecology, National University Hospital, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
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MeSH Terms
Body Weight
Isoflavones / pharmacology*
Laser-Doppler Flowmetry
Menopause / drug effects*
Models, Animal
Phytoestrogens / pharmacology*
Plant Preparations / pharmacology*
Sexual Dysfunction, Physiological / drug therapy
Vagina / blood supply,  innervation
Reg. No./Substance:
0/Isoflavones; 0/Phytoestrogens; 0/Plant Preparations

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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