| Efficacy and quality of life outcomes in patients with atypical trigeminal neuralgia treated with gamma-knife radiosurgery. | |
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MedLine Citation:
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PMID: 17467919 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To assess efficacy and quality of life (QOL) outcomes associated with gamma-knife radiosurgery (GK-RS) in treating atypical trigeminal neuralgia (ATN) compared with classic trigeminal neuralgia (CTN). METHODS AND MATERIALS: Between September 1996 and September 2004, 35 cases of ATN were treated with GK-RS. Patients were categorized into two groups: Group I comprised patients presenting with ATN (57%); Group II consisted of patients presenting with CTN then progressing to ATN (43%). Median prescription dose 75 Gy (range, 70-80 Gy) was delivered to trigeminal nerve root entry zone. Treatment efficacy and QOL improvements were assessed with a standardized questionnaire. RESULTS: With median follow-up of 29 months (range, 3-74 months), 72% reported excellent/good outcomes, with mean time to relief of 5.8 weeks (range, 0-24 weeks) and mean duration of relief of 62 weeks (range, 1-163 weeks). This rate of pain relief is similar to rate achieved in our previously reported experience treating CTN with GK-RS (p = 0.36). There was a trend toward longer time to relief (p = 0.059), and shorter duration of relief (p = 0.067) in patients with ATN. There was no difference in rate of, time to, or duration of pain relief between Groups I and II. Of the patients with ATN, 88% discontinued or decreased the use of pain medications. Among the patients with sustained pain relief, QOL improved an average of 85%. CONCLUSION: This is the largest reported GK-RS experience for the treatment of ATN. Patients with ATN can achieve rates of pain relief similar to those in patients with CTN. Further follow-up is necessary to assess adequately the durability of response. |
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Authors:
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Anil Dhople; Young Kwok; Lawrence Chin; David Shepard; Robert Slawson; Pradip Amin; William Regine |
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Publication Detail:
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Type: Journal Article Date: 2007-04-30 |
Journal Detail:
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Title: International journal of radiation oncology, biology, physics Volume: 69 ISSN: 0360-3016 ISO Abbreviation: Int. J. Radiat. Oncol. Biol. Phys. Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-09-17 Completed Date: 2007-11-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603616 Medline TA: Int J Radiat Oncol Biol Phys Country: United States |
Other Details:
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Languages: eng Pagination: 397-403 Citation Subset: IM |
Affiliation:
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Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. adhople@umm.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Analgesics / therapeutic use Female Follow-Up Studies Humans Male Middle Aged Quality of Life* Radiosurgery / instrumentation, methods* Time Factors Treatment Outcome Trigeminal Neuralgia / surgery* |
| Chemical | |
Reg. No./Substance:
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0/Analgesics |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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