Document Detail


Efficacy and quality of life outcomes in patients with atypical trigeminal neuralgia treated with gamma-knife radiosurgery.
MedLine Citation:
PMID:  17467919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To assess efficacy and quality of life (QOL) outcomes associated with gamma-knife radiosurgery (GK-RS) in treating atypical trigeminal neuralgia (ATN) compared with classic trigeminal neuralgia (CTN). METHODS AND MATERIALS: Between September 1996 and September 2004, 35 cases of ATN were treated with GK-RS. Patients were categorized into two groups: Group I comprised patients presenting with ATN (57%); Group II consisted of patients presenting with CTN then progressing to ATN (43%). Median prescription dose 75 Gy (range, 70-80 Gy) was delivered to trigeminal nerve root entry zone. Treatment efficacy and QOL improvements were assessed with a standardized questionnaire. RESULTS: With median follow-up of 29 months (range, 3-74 months), 72% reported excellent/good outcomes, with mean time to relief of 5.8 weeks (range, 0-24 weeks) and mean duration of relief of 62 weeks (range, 1-163 weeks). This rate of pain relief is similar to rate achieved in our previously reported experience treating CTN with GK-RS (p = 0.36). There was a trend toward longer time to relief (p = 0.059), and shorter duration of relief (p = 0.067) in patients with ATN. There was no difference in rate of, time to, or duration of pain relief between Groups I and II. Of the patients with ATN, 88% discontinued or decreased the use of pain medications. Among the patients with sustained pain relief, QOL improved an average of 85%. CONCLUSION: This is the largest reported GK-RS experience for the treatment of ATN. Patients with ATN can achieve rates of pain relief similar to those in patients with CTN. Further follow-up is necessary to assess adequately the durability of response.
Authors:
Anil Dhople; Young Kwok; Lawrence Chin; David Shepard; Robert Slawson; Pradip Amin; William Regine
Related Documents :
18506329 - Radiosurgery with a linear accelerator in cerebral arteriovenous malformations.
18503339 - Repeated gamma knife surgery for refractory trigeminal neuralgia.
11944589 - Etizolam, an anti-anxiety agent, attenuates recurrence of chronic subdural hematoma--ev...
19730779 - Outcome of fully awake craniotomy for lesions near the eloquent cortex: analysis of a p...
19199449 - Outcome after hemorrhage following gamma knife surgery for cerebral arteriovenous malfo...
20584469 - Endovascular treatment of cerebral avm: our experience with onyx.
23348639 - Ingestion of glutamine and maltodextrin two hours preoperatively improves insulin sensi...
15877939 - Pubovaginal bone anchor fixation with polyethylene versus fascia lata slings in the tre...
17965529 - Peritoneovenous shunts for palliation of malignant ascites.
Publication Detail:
Type:  Journal Article     Date:  2007-04-30
Journal Detail:
Title:  International journal of radiation oncology, biology, physics     Volume:  69     ISSN:  0360-3016     ISO Abbreviation:  Int. J. Radiat. Oncol. Biol. Phys.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-17     Completed Date:  2007-11-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603616     Medline TA:  Int J Radiat Oncol Biol Phys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  397-403     Citation Subset:  IM    
Affiliation:
Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. adhople@umm.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Analgesics / therapeutic use
Female
Follow-Up Studies
Humans
Male
Middle Aged
Quality of Life*
Radiosurgery / instrumentation,  methods*
Time Factors
Treatment Outcome
Trigeminal Neuralgia / surgery*
Chemical
Reg. No./Substance:
0/Analgesics

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Manipulation of catechol-O-methyl-transferase (COMT) activity to influence the attenuation of substa...
Next Document:  Analysis of treatment efficacy, cosmesis, and toxicity using the MammoSite breast brachytherapy cath...