Document Detail

Efficacy and quality of life outcomes in patients with atypical trigeminal neuralgia treated with gamma-knife radiosurgery.
MedLine Citation:
PMID:  17467919     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To assess efficacy and quality of life (QOL) outcomes associated with gamma-knife radiosurgery (GK-RS) in treating atypical trigeminal neuralgia (ATN) compared with classic trigeminal neuralgia (CTN). METHODS AND MATERIALS: Between September 1996 and September 2004, 35 cases of ATN were treated with GK-RS. Patients were categorized into two groups: Group I comprised patients presenting with ATN (57%); Group II consisted of patients presenting with CTN then progressing to ATN (43%). Median prescription dose 75 Gy (range, 70-80 Gy) was delivered to trigeminal nerve root entry zone. Treatment efficacy and QOL improvements were assessed with a standardized questionnaire. RESULTS: With median follow-up of 29 months (range, 3-74 months), 72% reported excellent/good outcomes, with mean time to relief of 5.8 weeks (range, 0-24 weeks) and mean duration of relief of 62 weeks (range, 1-163 weeks). This rate of pain relief is similar to rate achieved in our previously reported experience treating CTN with GK-RS (p = 0.36). There was a trend toward longer time to relief (p = 0.059), and shorter duration of relief (p = 0.067) in patients with ATN. There was no difference in rate of, time to, or duration of pain relief between Groups I and II. Of the patients with ATN, 88% discontinued or decreased the use of pain medications. Among the patients with sustained pain relief, QOL improved an average of 85%. CONCLUSION: This is the largest reported GK-RS experience for the treatment of ATN. Patients with ATN can achieve rates of pain relief similar to those in patients with CTN. Further follow-up is necessary to assess adequately the durability of response.
Anil Dhople; Young Kwok; Lawrence Chin; David Shepard; Robert Slawson; Pradip Amin; William Regine
Related Documents :
19751869 - Gamma knife radiosurgery for vestibular schwannoma.
18503339 - Repeated gamma knife surgery for refractory trigeminal neuralgia.
12904269 - Risk of whole body radiation exposure and protective measures in fluoroscopically guide...
23910089 - Magnetic resonance imaging-guided cryoablation of recurrent prostate cancer after radic...
18506329 - Radiosurgery with a linear accelerator in cerebral arteriovenous malformations.
21924859 - Migration of endobutton after anatomic double-bundle anterior cruciate ligament reconst...
3600909 - Quantitative analysis of mesangial areas in serial biopsied patients with iga nephropathy.
14634879 - Pitfalls in surgery of meningeomas of the free tentorial edge.
14609689 - Comparison of allograft to autograft in multilevel anterior cervical discectomy and fus...
Publication Detail:
Type:  Journal Article     Date:  2007-04-30
Journal Detail:
Title:  International journal of radiation oncology, biology, physics     Volume:  69     ISSN:  0360-3016     ISO Abbreviation:  Int. J. Radiat. Oncol. Biol. Phys.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-17     Completed Date:  2007-11-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603616     Medline TA:  Int J Radiat Oncol Biol Phys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  397-403     Citation Subset:  IM    
Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Analgesics / therapeutic use
Follow-Up Studies
Middle Aged
Quality of Life*
Radiosurgery / instrumentation,  methods*
Time Factors
Treatment Outcome
Trigeminal Neuralgia / surgery*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Manipulation of catechol-O-methyl-transferase (COMT) activity to influence the attenuation of substa...
Next Document:  Analysis of treatment efficacy, cosmesis, and toxicity using the MammoSite breast brachytherapy cath...