| Efficacy of a quadrivalent vaccine against respiratory diseases caused by BHV-1, PI3V, BVDV and BRSV in experimentally infected calves. | |
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MedLine Citation:
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PMID: 17276108 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The efficacy of a quadrivalent vaccine against viral bovine respiratory diseases (BRD) was assessed in four experimental studies. Calves between 2 and 9 months of age were allocated to one of two treatment groups (n=9-15) and then received either the vaccine or sterile saline in two doses approximately 3 weeks apart. Three to 5 weeks after the second injection, animals were challenged experimentally with one of the viruses, bovine herpes-virus-1 (BHV-1), parainfluenza type-3 virus (PI(3)V), bovine viral-diarrhoea virus type 1 (BVDV), or bovine respiratory syncytial virus (BRSV) and were then monitored for at least 2 weeks. The administration of the vaccine was associated with enhanced antibody response to all four viruses post-challenge, with the reduction of the amount or duration (or both) of virus shedding in the BHV-1, PI(3)V, BVDV and BRSV studies and with an improvement of some clinical signs in the BHV-1 (nasal discharge, and rectal temperature) and the PI(3)V studies (abnormal respiration, and depression). |
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Authors:
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J S Salt; S J Thevasagayam; A Wiseman; A R Peters |
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Publication Detail:
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Type: Controlled Clinical Trial; Journal Article Date: 2007-02-02 |
Journal Detail:
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Title: Veterinary journal (London, England : 1997) Volume: 174 ISSN: 1090-0233 ISO Abbreviation: Vet. J. Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-11-20 Completed Date: 2008-02-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9706281 Medline TA: Vet J Country: England |
Other Details:
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Languages: eng Pagination: 616-26 Citation Subset: IM |
Affiliation:
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Veterinary Medicine Research and Development, Biologicals, Pfizer Animal Health Sandwich, CT13 9NJ, United Kingdom. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Viral / blood Bovine Virus Diarrhea-Mucosal Disease / immunology, prevention & control*, virology Cattle Cattle Diseases / immunology, prevention & control*, virology* Diarrhea Viruses, Bovine Viral / immunology Herpesviridae Infections / immunology, prevention & control, veterinary* Herpesvirus 1, Bovine / immunology Parainfluenza Virus 3, Bovine / immunology Respiratory Syncytial Virus Infections / immunology, prevention & control, veterinary* Respiratory Syncytial Virus, Bovine / immunology Respiratory Tract Infections / prevention & control, veterinary*, virology Respirovirus Infections / immunology, prevention & control, veterinary Viral Vaccines / immunology* Viremia Virus Shedding |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Viral; 0/Viral Vaccines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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