Document Detail


Efficacy of a quadrivalent vaccine against respiratory diseases caused by BHV-1, PI3V, BVDV and BRSV in experimentally infected calves.
MedLine Citation:
PMID:  17276108     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The efficacy of a quadrivalent vaccine against viral bovine respiratory diseases (BRD) was assessed in four experimental studies. Calves between 2 and 9 months of age were allocated to one of two treatment groups (n=9-15) and then received either the vaccine or sterile saline in two doses approximately 3 weeks apart. Three to 5 weeks after the second injection, animals were challenged experimentally with one of the viruses, bovine herpes-virus-1 (BHV-1), parainfluenza type-3 virus (PI(3)V), bovine viral-diarrhoea virus type 1 (BVDV), or bovine respiratory syncytial virus (BRSV) and were then monitored for at least 2 weeks. The administration of the vaccine was associated with enhanced antibody response to all four viruses post-challenge, with the reduction of the amount or duration (or both) of virus shedding in the BHV-1, PI(3)V, BVDV and BRSV studies and with an improvement of some clinical signs in the BHV-1 (nasal discharge, and rectal temperature) and the PI(3)V studies (abnormal respiration, and depression).
Authors:
J S Salt; S J Thevasagayam; A Wiseman; A R Peters
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article     Date:  2007-02-02
Journal Detail:
Title:  Veterinary journal (London, England : 1997)     Volume:  174     ISSN:  1090-0233     ISO Abbreviation:  Vet. J.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-20     Completed Date:  2008-02-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9706281     Medline TA:  Vet J     Country:  England    
Other Details:
Languages:  eng     Pagination:  616-26     Citation Subset:  IM    
Affiliation:
Veterinary Medicine Research and Development, Biologicals, Pfizer Animal Health Sandwich, CT13 9NJ, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Viral / blood
Bovine Virus Diarrhea-Mucosal Disease / immunology,  prevention & control*,  virology
Cattle
Cattle Diseases / immunology,  prevention & control*,  virology*
Diarrhea Viruses, Bovine Viral / immunology
Herpesviridae Infections / immunology,  prevention & control,  veterinary*
Herpesvirus 1, Bovine / immunology
Parainfluenza Virus 3, Bovine / immunology
Respiratory Syncytial Virus Infections / immunology,  prevention & control,  veterinary*
Respiratory Syncytial Virus, Bovine / immunology
Respiratory Tract Infections / prevention & control,  veterinary*,  virology
Respirovirus Infections / immunology,  prevention & control,  veterinary
Viral Vaccines / immunology*
Viremia
Virus Shedding
Chemical
Reg. No./Substance:
0/Antibodies, Viral; 0/Viral Vaccines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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