Document Detail


Efficacy of pyrantel pamoate and ivermectin paste formulations against naturally acquired Oxyuris equi infections in horses.
MedLine Citation:
PMID:  20307935     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In recent years, numerous veterinary practitioners have reported anecdotal episodes in which anthelmintic treatment did not appear to deliver the expected efficacy against equine pinworms (Oxyuris equi). Anthelmintic resistance has not been demonstrated formally in equine pinworms, so a clinical study was designed to evaluate the efficacy of paste formulations of pyrantel pamoate or ivermectin against naturally acquired infections with O. equi. Twenty-one horses (>4 months to 15 years of age) with patent, naturally acquired pinworm infections were blocked by source of origin and allocated randomly to one of three treatment groups: horses (n=7) assigned to Group 1 were treated orally with pyrantel pamoate paste at a dosage of 13.2 mg/kg (2x label dosage), Group 2 horses (n=7) were untreated controls, and horses (n=7) assigned to Group 3 were treated orally with ivermectin paste at a dosage of 200 microg/kg. Fourteen days after treatment, horses were euthanatized, necropsied, and large intestinal contents were processed for recovery of adult pinworms. In addition, duplicate 1% aliquots of intestinal contents from the cecum, ventral colon, dorsal colon, and small colon were collected, preserved, and examined for recovery and enumeration of fourth-stage larval O. equi. Anthelmintic efficacy against pinworms was evaluated by comparing the post-treatment worm counts of Groups 1 and 3 to those of control animals. Mean numbers of O. equi adults recovered postmortem were significantly decreased by both pyrantel pamoate (P=0.0366) and ivermectin (P=0.0137) treatment, with respective efficacies of 91.2% and 96.0%. In addition, both products demonstrated >99% efficacy against fourth-stage O. equi larvae. The current study demonstrated acceptable adulticidal and larvicidal efficacy of both pyrantel pamoate and ivermectin paste formulations against O. equi and did not support the existence of macrocyclic lactone or pyrimidine resistance in the pinworm populations evaluated.
Authors:
Craig R Reinemeyer; Julio C Prado; Eric C Nichols; Alan A Marchiondo
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-03
Journal Detail:
Title:  Veterinary parasitology     Volume:  171     ISSN:  1873-2550     ISO Abbreviation:  Vet. Parasitol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-23     Completed Date:  2010-09-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7602745     Medline TA:  Vet Parasitol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  106-10     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier B.V. All rights reserved.
Affiliation:
East Tennessee Clinical Research, Inc., 80 Copper Ridge Farm Road, Rockwood, TN 37854, United States. crr@easttenncr.com
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Anthelmintics / administration & dosage,  pharmacology*,  standards,  therapeutic use
Enterobiasis / drug therapy,  parasitology,  veterinary*
Enterobius / growth & development*
Feces / parasitology
Gastrointestinal Diseases / drug therapy,  parasitology,  veterinary*
Horse Diseases / drug therapy,  parasitology*
Horses
Ivermectin / administration & dosage,  pharmacology*,  standards,  therapeutic use
Least-Squares Analysis
Parasite Egg Count / veterinary
Pyrantel Pamoate / administration & dosage,  pharmacology*,  standards,  therapeutic use
Random Allocation
Single-Blind Method
Chemical
Reg. No./Substance:
0/Anthelmintics; 22204-24-6/Pyrantel Pamoate; 70288-86-7/Ivermectin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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