Document Detail


Efficacy of propranolol therapy after acute myocardial infarction related to coronary arterial anatomy and left ventricular function.
MedLine Citation:
PMID:  3673915     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of the beta-adrenergic blocking agent propranolol on morbidity and mortality risk after acute myocardial infarction was studied relative to coronary anatomy and left ventricular (LV) ejection fraction in a subset of 406 patients participating in a randomized study of 3,837 patients in the Beta Blocker Heart Attack Trial (BHAT). Median follow-up for this subset of patients was 28 months. The mortality rate was 2% (2 of 100) in patients with 2- and 3-vessel coronary artery disease taking propranolol and 10% (12 of 126) in those taking placebo (p less than 0.02). In patients with 2- and 3-vessel coronary artery disease with decreased LV function (defined as ejection fraction less than 50%), no patient taking propranolol died, whereas 17% (7 of 42) taking placebo died (p less than 0.04). The salutary effect of propranolol on mortality in the larger BHAT after acute myocardial infarction also was evident in this population studied in regard to their coronary and LV anatomy and function.
Authors:
S M Jafri; F Khaja; T McFarland; R Capone; S Dahdah; J Haywood; W A Edmiston; B Tilley; L Schultz; S Goldstein
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The American journal of cardiology     Volume:  60     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1987-12-17     Completed Date:  1987-12-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  976-80     Citation Subset:  AIM; IM    
Affiliation:
Henry Ford Heart and Vascular Institute, Department of Medicine, Henry Ford Hospital, Detroit, Michigan 48202.
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MeSH Terms
Descriptor/Qualifier:
Coronary Vessels / pathology*
Female
Humans
Male
Middle Aged
Myocardial Infarction / drug therapy*,  mortality,  physiopathology
Propranolol / therapeutic use*
Risk Factors
Stroke Volume*
Chemical
Reg. No./Substance:
525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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