Document Detail

Efficacy of prophylactic droperidol, ondansetron or both in the prevention of postoperative nausea and vomiting in major gynaecological surgery. A prospective, randomized, double-blind clinical trial.
MedLine Citation:
PMID:  11050518     Owner:  NLM     Status:  MEDLINE    
We conducted a prospective, randomized, double-blind clinical trial comparing droperidol 1.25 mg intravenously (i.v.) (group 1, n = 30), ondansetron 4 mg i.v. (group 2, n = 30), or both (group 3, n = 30) in the prevention of postoperative nausea and vomiting (PONV) in the first 24 h following major gynaecological procedures under combined general and epidural anaesthesia. PONV was analysed by a linear nausea/vomiting score, incidence of nausea and vomiting, and the need for antiemetic rescue. Our results showed a similar incidence of nausea and vomiting in all groups (G1 33%, G2 40%, G3 43%). However, when comparisons were made according to the time of assessment, combination therapy resulted in significantly lower PONV than droperidol in the first hour (0% vs. 13%, P < 0.05) and second hour (0% vs. 13%, P < 0.05), and than ondansetron on the first hour (0% vs. 13%, P < 0.05). A trend persisted up to the fourth hour but was not statistically significant in either group. In conclusion, droperidol and ondansetron are effective agents in the prevention of PONV, and their combination seems to provide slightly better results than either drug alone.
A J Peixoto; A J Peixoto Filho; L F Leães; M F Celich; M A Barros
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European journal of anaesthesiology     Volume:  17     ISSN:  0265-0215     ISO Abbreviation:  Eur J Anaesthesiol     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-11-16     Completed Date:  2000-11-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8411711     Medline TA:  Eur J Anaesthesiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  611-5     Citation Subset:  IM    
Department of Anesthesiology, Hospital de Caridade, Erechim, RS, Brazil.
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MeSH Terms
Aged, 80 and over
Antiemetics / administration & dosage,  therapeutic use*
Double-Blind Method
Droperidol / administration & dosage,  therapeutic use*
Drug Therapy, Combination
Gynecologic Surgical Procedures*
Middle Aged
Ondansetron / administration & dosage,  therapeutic use*
Postoperative Nausea and Vomiting / prevention & control*
Prospective Studies
Reg. No./Substance:
0/Antiemetics; 548-73-2/Droperidol; 99614-02-5/Ondansetron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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