Document Detail

Efficacy of prophylactic anti-diarrhoeal treatment in patients receiving Campto for advanced colorectal cancer.
MedLine Citation:
PMID:  12552984     Owner:  NLM     Status:  MEDLINE    
This study assessed the efficacy of combined prophylactic and curative anti-diarrhoeal medication in advanced colorectal patients treated by irinotecan. Thirty-four pre-treated eligible patients were evaluated. There were 44% women, the median age was 65 and 38% of the patients had a 0 performance status. The patients received sucralfate(4g/d) and nifuroxazide(600 mg/d) prophylactic treatment on days 0-7. In the case of severe diarrhoea, preventive treatment was replaced by loperamide(12 mg/d) and diosmectite (9 g/d). Grade 3 delayed diarrhoea occurred in 18% of patients (90% CI: [9.5-28.9]) and 4.6% of cycles. No grade 4 delayed diarrhoea was observed. Twenty-nine patients (85%) received the preventive treatment at cycle 1, while 14% (90% CI: [6.2-25.7]) experienced grade 3 delayed diarrhoea in 3.7% of cycles for a median 4.5 days. The objective response rate was 8% (90% CI [1.4-23.1]) among the 25 assessable patients. Preventive combined treatment is effective in reducing the incidence of severe delayed diarrhoea, and it should be proposed to patients treated with mono-therapy Campto(r) and evaluated in poly-chemotherapy protocols.
J Duffour; S Gourgou; J F Seitz; P Senesse; O Boutet; D Castera; A Kramar; M Ychou
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study    
Journal Detail:
Title:  Anticancer research     Volume:  22     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    2002 Nov-Dec
Date Detail:
Created Date:  2003-01-29     Completed Date:  2003-02-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  3727-31     Citation Subset:  IM    
Hopital La Timone, 264 rue St-Pierre, Marseille, France.
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MeSH Terms
Adenocarcinoma / complications,  drug therapy*
Anti-Infective Agents / therapeutic use
Anti-Ulcer Agents / therapeutic use
Antidiarrheals / therapeutic use*
Antineoplastic Agents, Phytogenic / adverse effects*,  therapeutic use
Camptothecin / adverse effects*,  analogs & derivatives*,  therapeutic use
Colorectal Neoplasms / complications,  drug therapy*
Diarrhea / chemically induced,  drug therapy,  prevention & control*
Gastrointestinal Agents / therapeutic use
Hydroxybenzoic Acids / therapeutic use*
Loperamide / therapeutic use
Middle Aged
Nitrofurans / therapeutic use*
Sucralfate / therapeutic use*
Reg. No./Substance:
0/Anti-Infective Agents; 0/Anti-Ulcer Agents; 0/Antidiarrheals; 0/Antineoplastic Agents, Phytogenic; 0/Gastrointestinal Agents; 0/Hydroxybenzoic Acids; 0/Nitrofurans; 0/Silicates; 100286-90-6/irinotecan; 12199-37-0/Smectite; 53179-11-6/Loperamide; 54182-58-0/Sucralfate; 7689-03-4/Camptothecin; 965-52-6/nifuroxazide
Erratum In:
Anticancer Res. 2003 Mar-Apr;23(2B):following 1648
Anticancer Res. 2003;23:5369

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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