Document Detail


Efficacy of prolonged antimicrobial chemotherapy for brucellar spondylodiscitis.
MedLine Citation:
PMID:  20518794     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
The standard treatment of brucellar spondylitis with a combination of two antibiotics for 6-12 weeks is associated with high rates of treatment failure and relapse. The present study aimed to assess the safety and efficacy of a treatment strategy based on the prolonged administration of a triple combination of suitable antibiotics. Eighteen patients with brucellar spondylitis were treated with a combination of at least three suitable antibiotics (doxycycline, rifampin, plus intramuscular streptomycin or cotrimoxazole or ciprofloxacin) until the completion of at least 6 months of treatment, when clinical, radiological and serology re-evaluation was performed. If necessary, the treatment was continued with additional 6-month cycles, until resolution or significant improvement of clinical and radiological findings, or for a maximum of 18 months. At presentation, the median age was 66 years (range, 42-85 years) with male predominance. The median duration of therapy was 48 weeks (range 24-72 weeks). Treatment was discontinued early because of side-effects in only one patient. Surgical intervention was required for three patients. At the end of treatment all patients had a complete response. After completion of treatment, all patients were followed up with regular visits. During the follow-up period (duration 1-96 months, median 36.5 months), no relapses were observed. In conclusion, prolonged (at least 6 months) administration of a triple combination of suitable antibiotics appears to be an effective treatment for brucellar spondylitis.
Authors:
S Ioannou; D Karadima; S Pneumaticos; H Athanasiou; J Pontikis; A Zormpala; N V Sipsas
Related Documents :
3746784 - Laparoscopic tubal sterilization combined with removal of an intrauterine contraceptive...
2021474 - Factors influencing palatoplasty and pharyngeal flap surgery.
6177664 - Intraoperative gram's staining of bile as a guide for early selective administration of...
20213514 - Prophylactic oral antibiotics reduce reinfection rates following two-stage revision tot...
10711884 - Outcome of sulcus fixation of dislocated posterior chamber intraocular lenses using tem...
20676154 - A longitudinal study of reproductive performance and management of 82 dairy herds in th...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases     Volume:  17     ISSN:  1469-0691     ISO Abbreviation:  Clin. Microbiol. Infect.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9516420     Medline TA:  Clin Microbiol Infect     Country:  France    
Other Details:
Languages:  eng     Pagination:  756-62     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. Clinical Microbiology and Infection © 2010 European Society of Clinical Microbiology and Infectious Diseases.
Affiliation:
Pathophysiology Department, Laikon General Hospital, and Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  High prevalence of methicillin-resistant Staphylococcus aureus clone ST80-IV in hospital and communi...
Next Document:  Temporal trends in Enterobacter species bloodstream infection: a population-based study from 1998-20...