Document Detail

Efficacy of progesterone support for pregnancy in women with recurrent miscarriage. A meta-analysis of controlled trials.
MedLine Citation:
PMID:  2653415     Owner:  NLM     Status:  MEDLINE    
Progesterone appears to be necessary to support an early pregnancy, and it has been used for this purpose for several decades. Its potential role in women with recurrent miscarriage due to luteal phase deficiency has been suggested, but its efficacy has not yet been demonstrated. Three controlled trials of progesterone treatment in women with recurrent miscarriage have shown small, but not statistically significant, increases in the rates of pregnancies that continue beyond 20 weeks in the treated groups. None of these studies had sufficient statistical power to detect a clinically significant improvement in outcome but pooling the results of these studies using the principles of meta-analysis has allowed an overall effect of treatment to be calculated. The resulting odds ratio for pregnancies reaching at least 20 weeks gestation was 3.09 (95% CI 1.28 to 7.42) which indicates that there is evidence to support the suggestion that progesterone given in early pregnancy is useful in women with recurrent miscarriage. Although, before progesterone is used in this way its efficacy in women with recurrent miscarriage due to luteal phase deficiency must be assessed in prospective double-blind randomized controlled trials mounted in the light of the results of this meta-analysis.
S Daya
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  96     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1989-06-21     Completed Date:  1989-06-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  275-80     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada.
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MeSH Terms
Abortion, Habitual / prevention & control*
Clinical Trials as Topic
Luteal Phase
Meta-Analysis as Topic
Pregnancy Outcome
Progesterone / therapeutic use*
Time Factors
Reg. No./Substance:
Comment In:
Br J Obstet Gynaecol. 1989 Mar;96(3):257-60   [PMID:  2653412 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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